Necrotizing fasciitis associated with sorafenib treatment

被引：4

作者：

Kang, Ho Won ^{[1
,2
]}

Yun, Seok-Joong ^{[1
,2
]}

Kim, Wun-Jae ^{[1
,2
]}

机构：

[1] Chungbuk Natl Univ, Coll Med, Dept Urol, Cheongju, South Korea

[2] Chungbuk Natl Univ Hosp, Dept Urol, Cheongju, South Korea

来源：

IDCASES | 2019年 / 18卷

关键词：

Necrotizing fasciitis; Adverse drug reaction; Tyrosine kinase inhibitors; Hepatocellular carcinoma; STAPHYLOCOCCUS-LUGDUNENSIS; KINASE INHIBITORS; BEVACIZUMAB;

D O I：

10.1016/j.idcr.2019.e00611

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We present here a case of extensive necrotizing fasciitis during sorafenib treatment in a patient with HBV-related hepatocellular carcinoma. Despite emergent extensive surgical debridement, the patient's clinical status progressive worsened until interruption of sorafenib therapy. The patient was successfully treated with temporal interruption of sorafenib therapy. To our knowledge, this is the first case report of sorafenib-associated necrotizing fasciitis. Given the life-threatening nature of the infection and the necessity for urgent intervention, clinicians should be aware of this possible adverse effect of tyrosine kinase inhibitors. (C) 2019 The Authors. Published by Elsevier Ltd.

引用

页数：3

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