Solid phase synthesis of indinavir and its analogues

被引:17
作者
Cheng, Y [1 ]
Lu, ZJ [1 ]
Chapman, KT [1 ]
Tata, JR [1 ]
机构
[1] Merck Res Labs, Basic Chem Dept, Combinatorial Chem Grp, Rahway, NJ 07065 USA
来源
JOURNAL OF COMBINATORIAL CHEMISTRY | 2000年 / 2卷 / 05期
关键词
D O I
10.1021/cc000029z
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
[No abstract available]
引用
收藏
页码:445 / 446
页数:2
相关论文
共 11 条
[1]  
ASKIN D, 1998, DRUG DISCOVERY DEV, V1, P338
[2]   Design, synthesis, and conformational analysis of a novel series of HIV protease inhibitors [J].
Baker, CT ;
Salituro, FG ;
Court, JJ ;
Deininger, DD ;
Kim, EE ;
Li, BQ ;
Novak, PM ;
Rao, BG ;
Pazhanisamy, S ;
Schairer, WC ;
Tung, RD .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (24) :3631-3636
[3]   HIV-1 protease inhibitors - A review for clinicians [J].
Deeks, SG ;
Smith, M ;
Holodniy, M ;
Kahn, JO .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (02) :145-153
[4]   L-735,524 - THE DESIGN OF A POTENT AND ORALLY BIOAVAILABLE HIV PROTEASE INHIBITOR [J].
DORSEY, BD ;
LEVIN, RB ;
MCDANIEL, SL ;
VACCA, JP ;
GUARE, JP ;
DARKE, PL ;
ZUGAY, JA ;
EMINI, EA ;
SCHLEIF, WA ;
QUINTERO, JC ;
LIN, JH ;
CHEN, IW ;
HOLLOWAY, MK ;
FITZGERALD, PMD ;
AXEL, MG ;
OSTOVIC, D ;
ANDERSON, PS ;
HUFF, JR .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (21) :3443-3451
[5]  
Kempf DJ, 1996, CURR PHARM DESIGN, V2, P225
[6]   EXPEDIENT METHOD FOR THE SOLID-PHASE SYNTHESIS OF ASPARTIC-ACID PROTEASE INHIBITORS DIRECTED TOWARD THE GENERATION OF LIBRARIES [J].
KICK, EK ;
ELLMAN, JA .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (09) :1427-1430
[7]   Cyclic imidate salts in acyclic stereochemistry: Diastereoselective syn-epoxidation of 2-alkyl-4-enamides to epoxyamides [J].
Maligres, PE ;
Weissman, SA ;
Upadhyay, V ;
Cianciosi, SJ ;
Reamer, RA ;
Purick, RM ;
Sager, J ;
Rossen, K ;
Eng, KK ;
Askin, D ;
Volante, RP ;
Reider, PJ .
TETRAHEDRON, 1996, 52 (09) :3327-3338
[8]   Mutational anatomy of an HIV-1 protease variant conferring cross-resistance to protease inhibitors in clinical trials - Compensatory modulations of binding and activity [J].
Schock, HB ;
Garsky, VM ;
Kuo, LC .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (50) :31957-31963
[9]   L-735,524 - AN ORALLY BIOAVAILABLE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PROTEASE INHIBITOR [J].
VACCA, JP ;
DORSEY, BD ;
SCHLEIF, WA ;
LEVIN, RB ;
MCDANIEL, SL ;
DARKE, PL ;
ZUGAY, J ;
QUINTERO, JC ;
BLAHY, OM ;
ROTH, E ;
SARDANA, VV ;
SCHLABACH, AJ ;
GRAHAM, PI ;
CONDRA, JH ;
GOTLIB, L ;
HOLLOWAY, MK ;
LIN, J ;
CHEN, IW ;
VASTAG, K ;
OSTOVIC, D ;
ANDERSON, PS ;
EMINI, EA ;
HUFF, JR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :4096-4100
[10]   Clinically effective HIV-1 protease inhibitors [J].
Vacca, JP ;
Condra, JH .
DRUG DISCOVERY TODAY, 1997, 2 (07) :261-272