A Closer Look to the Evolution of Neurons in Humans and Apes Using Stem-Cell-Derived Model Systems

被引：0
作者：
Schornig, Maria [1 ,2 ]
Taverna, Elena [1 ]
机构：
[1] Max Planck Inst Evolutionary Anthropol, Leipzig, Germany
[2] Univ Klinikum Jena, Inst Biochem Nonnenplan 1, Jena, Germany
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷
关键词：
stem cell; model system; primate; neuroscience; brain evolution; comparative neurobiology; iPS cells; COVERAGE NEANDERTHAL GENOME; CEREBRAL ORGANOIDS; PYRAMIDAL NEURONS; DENDRITIC MORPHOLOGY; BRAIN; DIFFERENTIATION; NEOCORTEX; DISEASE; CORTEX; INDUCTION;
D O I：
10.3389/fcell.2021.661113
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The cellular, molecular and functional comparison of neurons from closely related species is crucial in evolutionary neurobiology. The access to living tissue and post-mortem brains of humans and non-human primates is limited and the state of the tissue might not allow recapitulating important species-specific differences. A valid alternative is offered by neurons derived from induced pluripotent stem cells (iPSCs) obtained from humans and non-human apes and primates. We will review herein the contribution of iPSCs-derived neuronal models to the field of evolutionary neurobiology, focusing on species-specific aspects of neuron's cell biology and timing of maturation. In addition, we will discuss the use of iPSCs for the study of ancient human traits.
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