A Closer Look to the Evolution of Neurons in Humans and Apes Using Stem-Cell-Derived Model Systems

被引：0

作者：

Schornig, Maria ^{[1
,2
]}

Taverna, Elena ^{[1
]}

机构：

[1] Max Planck Inst Evolutionary Anthropol, Leipzig, Germany

[2] Univ Klinikum Jena, Inst Biochem Nonnenplan 1, Jena, Germany

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

关键词：

stem cell; model system; primate; neuroscience; brain evolution; comparative neurobiology; iPS cells; COVERAGE NEANDERTHAL GENOME; CEREBRAL ORGANOIDS; PYRAMIDAL NEURONS; DENDRITIC MORPHOLOGY; BRAIN; DIFFERENTIATION; NEOCORTEX; DISEASE; CORTEX; INDUCTION;

D O I：

10.3389/fcell.2021.661113

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cellular, molecular and functional comparison of neurons from closely related species is crucial in evolutionary neurobiology. The access to living tissue and post-mortem brains of humans and non-human primates is limited and the state of the tissue might not allow recapitulating important species-specific differences. A valid alternative is offered by neurons derived from induced pluripotent stem cells (iPSCs) obtained from humans and non-human apes and primates. We will review herein the contribution of iPSCs-derived neuronal models to the field of evolutionary neurobiology, focusing on species-specific aspects of neuron's cell biology and timing of maturation. In addition, we will discuss the use of iPSCs for the study of ancient human traits.

引用

页数：7

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