Endothelial glycocalyx in traumatic brain injury associated coagulopathy: potential mechanisms and impact

被引：36

作者：

Zou, Zhimin ^{[1
,2
,3
]}

Li, Li ^{[1
,2
]}

Schafer, Nadine ^{[4
]}

Huang, Qiaobing ^{[1
,2
,3
]}

Maegele, Marc ^{[1
,2
,4
,5
]}

Gu, Zhengtao ^{[1
,2
]}

机构：

[1] Southern Med Univ, Affiliated Hosp 3, Guangdong Prov Key Lab Bone & Joint Degenerat Dis, Acad Orthoped Guangdong Prov, Guangzhou 515630, Guangdong, Peoples R China

[2] Southern Med Univ, Affiliated Hosp 3, Dept Treatment Ctr Traumat Injuries, Guangzhou 515630, Guangdong, Peoples R China

[3] Southern Med Univ, Sch Basic Med Sci, Guangdong Prov Key Lab Shock & Microcirculat, Dept Pathophysiol, Guangzhou 510515, Peoples R China

[4] Univ Witten Herdecke UW H, Inst Res Operat Med IFOM, Campus Cologne Merheim,Ostmerheimerstr 200, D-51109 Cologne, Germany

[5] Univ Witten Herdecke UW H, Cologne Merheim Med Ctr CMMC, Dept Trauma & Orthoped Surg, Campus Cologne Merheim,Ostmerheimerstr 200, D-51109 Cologne, Germany

来源：

JOURNAL OF NEUROINFLAMMATION | 2021年 / 18卷 / 01期

基金：

中国博士后科学基金;

关键词：

Traumatic brain injury; Coagulopathy; Endothelial glycocalyx; HEPARAN-SULFATE PROTEOGLYCANS; 6-PERCENT HYDROXYETHYL STARCH; OXIDATIVE STRESS; CELL GLYCOCALYX; SHEAR-STRESS; SYMPATHOADRENAL ACTIVATION; SYMPATHETIC HYPERACTIVITY; MATRIX METALLOPROTEINASES; VASCULAR-PERMEABILITY; COAGULATION DISORDERS;

D O I：

10.1186/s12974-021-02192-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Traumatic brain injury (TBI) remains one of the leading causes of death and disability worldwide; more than 10 million people are hospitalized for TBI every year around the globe. While the primary injury remains unavoidable and not accessible to treatment, the secondary injury which includes oxidative stress, inflammation, excitotoxicity, but also complicating coagulation abnormalities, is potentially avoidable and profoundly affects the therapeutic process and prognosis of TBI patients. The endothelial glycocalyx, the first line of defense against endothelial injury, plays a vital role in maintaining the delicate balance between blood coagulation and anticoagulation. However, this component is highly vulnerable to damage and also difficult to examine. Recent advances in analytical techniques have enabled biochemical, visual, and computational investigation of this vascular component. In this review, we summarize the current knowledge on (i) structure and function of the endothelial glycocalyx, (ii) its potential role in the development of TBI associated coagulopathy, and (iii) the options available at present for detecting and protecting the endothelial glycocalyx.

引用

页数：16