Heat Shock Proteins in Lymphoma Immunotherapy

被引:12
作者
Albakova, Zarema [1 ,2 ]
Mangasarova, Yana [3 ]
Sapozhnikov, Alexander [1 ,2 ]
机构
[1] Lomonosov Moscow State Univ, Dept Biol, Moscow, Russia
[2] RAS, Dept Immunol, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow, Russia
[3] Natl Res Ctr Hematol, Moscow, Russia
来源
FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷
关键词
heat shock proteins; lymphoma; CAR T; CAR NK; checkpoint inhibitors; SMALL-MOLECULE INHIBITOR; HEAT-SHOCK-PROTEIN-70; HSP70; FOLLICULAR LYMPHOMA; NK CELLS; SERUM-LEVELS; IN-VITRO; HODGKIN; HSP90; MACROPHAGES; TUMOR;
D O I
10.3389/fimmu.2021.660085
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunotherapy harnessing the host immune system for tumor destruction revolutionized oncology research and advanced treatment strategies for lymphoma patients. Lymphoma is a heterogeneous group of cancer, where the central roles in pathogenesis play immune evasion and dysregulation of multiple signaling pathways. Immunotherapy-based approaches such as engineered T cells (CAR T), immune checkpoint modulators and NK cell-based therapies are now in the frontline of lymphoma research. Even though emerging immunotherapies showed promising results in treating lymphoma patients, low efficacy and on-target/off-tumor toxicity are of a major concern. To address that issue it is suggested to look into the emerging role of heat shock proteins. Heat shock proteins (HSPs) showed to be highly expressed in lymphoma cells. HSPs are known for their abilities to modulate immune responses and inhibit apoptosis, which made their successful entry into cancer clinical trials. Here, we explore the role of HSPs in Hodgkin and Non-Hodgkin lymphoma and their involvement in CAR T therapy, checkpoint blockade and NK cell- based therapies. Understanding the role of HSPs in lymphoma pathogenesis and the ways how HSPs may enhance anti-tumor responses, may help in the development of more effective, specific and safe immunotherapy.
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页数:16
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