Synthesis and Antileishmanial Activity of Lipidic Amino Alcohols

被引：21

作者：

Coimbra, Elaine S. ^{[2
]}

de Almeida, Mauro V. ^{[1
]}

Junior, Celso O. R. ^{[1
]}

Taveira, Aline F. ^{[1
]}

da Costa, Cristiane F. ^{[1
]}

de Almeida, Ana C. ^{[2
]}

Reis, Elaine F. C. ^{[1
]}

da Silva, Adilson D. ^{[1
]}

机构：

[1] Univ Fed Juiz de Fora, Inst Ciencias Exatas, Dept Quim, BR-36036900 Juiz De Fora, MG, Brazil

[2] Univ Fed Juiz de Fora, Dept Parasitol Microbiol & Imunol, Inst Ciencias Biol, BR-36036900 Juiz De Fora, MG, Brazil

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2010年 / 75卷 / 02期

关键词：

amino alcohols; antileishmanial activity; lipophilicity; LEISHMANIASIS; CHEMOTHERAPY; METABOLISM; DIAMINES;

D O I：

10.1111/j.1747-0285.2009.00923.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this work, a number of lipidic amino alcohols wereas synthesized and evaluated in vitro on cultures of Leishmania amazonensis and Leishmania chagasi. Nine amino alcohols showed inhibition of L. chagasi growth, and seven of them showed inhibition of L. amazonensis with IC50 below 10 mu m. Compound 11f was more active than the reference drug amphotericin B against L. chagasi promastigote forms.

引用

页码：233 / 235

页数：3

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