Trace determination of pharmaceuticals and other wastewater-derived micropollutants by solid phase extraction and gas chromatography/mass spectrometry

被引：72

作者：

Bisceglia, Kevin J. ^{[1
]}

Yu, Jim T. ^{[1
]}

Coelhan, Mehmet ^{[2
]}

Bouwer, Edward J. ^{[1
]}

Roberts, A. Lynn ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Geog & Environm Engn, Baltimore, MD 21218 USA

[2] Tech Univ Munich, Res Ctr Weihenstephan Brewing & Food Qual, D-8000 Munich, Germany

来源：

JOURNAL OF CHROMATOGRAPHY A | 2010年 / 1217卷 / 04期

基金：

美国国家环境保护局;

关键词：

Gas chromatography/mass spectrometry; PPCPS; Pharmaceuticals; Wastewater; Sewage; Environmental occurrence; NATIONAL RECONNAISSANCE; EMERGING CONTAMINANTS; MASS SPECTROMETRY; CURRENT ISSUES; UNITED-STATES; GC-MS; DRUGS; RESIDUES; DERIVATIZATION; METABOLITES;

D O I：

10.1016/j.chroma.2009.11.062

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of pharmaceuticals and other wastewater-derived micropollutants in surface and groundwaters is receiving intense public and scientific attention. Yet simple GC/MS methods that would enable measurement of a wide range of such compounds are scarce. This paper describes a GC/MS method for the simultaneous determination of 13 pharmaceuticals (acetaminophen, albuterol, allopurinol, amitriptyline, brompheniramine, carbamazepine, carisoprodol, ciclopirox, diazepain, fenofibrate, metoprolol, primidone, and terbinafine) and 5 wastewater-derived contaminants (caffeine, diethyltoluamide, n-butylbenzene sulfonamide, n-nonylphenol, and n-octylphenol) by solid phase extraction (SPE) and derivatization with BSTFA. The method was applied to the analysis of raw and treated sewage samples obtained from a wastewater treatment plant located in the mid-Atlantic United States. All analytes were detected in untreated sewage, and 14 of the 18 analytes were detected in treated sewage. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：558 / 564

页数：7

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