IgG4-related disease: Historical overview and pathology of hematological disorders

被引：218

作者：

Sato, Yasuharu

Notohara, Kenji ^{[2
]}

Kojima, Masaru ^{[3
]}

Takata, Katsuyoshi

Masaki, Yasufumi ^{[4
]}

Yoshino, Tadashi ^{[1
]}

机构：

[1] Okayama Univ, Dept Pathol, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, Okayama 7008558, Japan

[2] Kurashiki Cent Hosp, Dept Pathol, Kurashiki, Okayama, Japan

[3] Dokkyo Univ, Sch Med, Dept Anat & Diagnost Pathol, Mibu, Tochigi 32102, Japan

[4] Kanazawa Med Univ, Dept Hematol & Immunol, Kahoku, Ishikawa 92002, Japan

来源：

PATHOLOGY INTERNATIONAL | 2010年 / 60卷 / 04期

关键词：

autoimmune pancreatitis; IgG4; lymph node; mucosa-associated lymphoid tissue lymphoma; ocular adnexa; CHRONIC SCLEROSING SIALADENITIS; ABDOMINAL AORTIC-ANEURYSM; IGG4-POSITIVE PLASMA-CELLS; AUTOIMMUNE PANCREATITIS; INFLAMMATORY PSEUDOTUMOR; LYMPH-NODES; SERUM IGG4; DIAGNOSTIC-CRITERIA; IMMUNOBLASTIC PROLIFERATION; SUBCLASS DISTRIBUTION;

D O I：

10.1111/j.1440-1827.2010.02524.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

IgG4-related diseases comprise a recently recognized systemic syndrome characterized by mass-forming lesions in mainly exocrine tissue that consist of lymphoplasmacytic infiltrates and sclerosis. There are numerous IgG4-positive plasma cells in the affected tissues, and the serum IgG4 level is increased in these patients. The present study describes the history, autoimmune pancreatitis (AIP), IgG4-related lymphadenopathy and lymphomagenesis based upon ocular adnexal IgG4-related disease. Lymphoplasmacytic sclerosing pancreatitis, a prototypal histological type of AIP, is now recognized as a systemic IgG4-related disease. Lymph node lesions can be subdivided into at least five histological subtypes, and systemic IgG4-related lymphadenopathy should be distinguished from multicentric Castleman's disease. Interleukin-6 and CRP levels are abnormally high in multicentric Castleman's disease, but are normal in the majority of systemic IgG4-related lymphadenopathy. Ocular adnexal IgG4-related disease frequently involves bilateral lacrimal glands swelling, and obliterative phlebitis is rare. Moreover, some malignant lymphomas, especially mucosa-associated lymphoid tissue lymphoma, arise from ocular adnexal IgG4-related disease. In addition, IgG4-producing lymphoma also exists.

引用

页码：247 / 258

页数：12

共 92 条

[1] Immunohistochemical study of autoimmune pancreatitis using anti-IgG4 antibody and patients' sera [J].