Predominance of HIV-1 subtype A and D infections in Uganda

被引：34

作者：

Hu, DJ

Baggs, J

Downing, RG

Pieniazek, D

Dorn, J

Fridlund, C

Biryahwaho, B

Sempala, SDK

Rayfield, MA

Dondero, TJ

Lal, R

机构：

[1] Ctr Dis Control & Prevent, Int Activities Branch, Div HIV AIDS Prevent, NCHSTP, Atlanta, GA 30333 USA

[2] State Washington, Dept Labor & Ind, Washington, DC USA

[3] Ctr Dis Control & Prevent Res Collaborat, Uganda Virus Res Inst, Entebbe, Uganda

来源：

EMERGING INFECTIOUS DISEASES | 2000年 / 6卷 / 06期

关键词：

D O I：

10.3201/eid0606.000609

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To better characterize the virus isolates associated with the HIV-1 epidemic in Uganda, 100 specimens from HIV-1-infected persons were randomly selected from each of two periods from late 1994 to late 1997. The 200 specimens were classified into HIV-1 subtypes by sequence-based phylogenetic analysis of the envelope (env) gp41 region; 98 (49%) were classified as env subtype A, 96 (48%) as D, 5 (2.5%) as C, and 1 was not classified as a known env subtype. Demographic characteristics of persons infected with the two principal HIV-1 subtypes, A and D, were Very similar, and the proportion of either subtype did not differ significantly between early and later periods. Our systematic characterization of the HIV-1 epidemic in Uganda over an almost 3-year period documented that the distribution and degree of genetic diversity of the HIV subtypes A and D are very similar and did not change appreciably over that time.

引用

页码：609 / 615

页数：7

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