Arterial Spin Labeling Blood Flow MRI: Its Role in the Early Characterization of Alzheimer's Disease

被引：169
作者：
Alsop, David C. [1 ,2 ]
Dai, Weiying [1 ,2 ]
Grossman, Murray [3 ]
Detre, John A. [3 ,4 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA
[4] Univ Penn, Med Ctr, Dept Radiol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 20卷 / 03期
关键词：
Cerebral blood flow; diagnosis; imaging; magnetic resonance imaging; perfusion; MILD COGNITIVE IMPAIRMENT; CASL-PERFUSION MRI; TRANSIT-TIME; CEREBRAL HYPOPERFUSION; GLUCOSE-METABOLISM; CSF BIOMARKERS; HUMAN BRAIN; INVERSION; FMRI; CBF;
D O I：
10.3233/JAD-2010-091699
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Arterial spin labeling (ASL) enables the noninvasive, quantitative imaging of cerebral blood flow using standard magnetic resonance imaging (MRI) equipment. Because it requires no contrast injection, ASL can add resting functional information to MRI studies measuring atrophy and signs of ischemic injury. Key features of ASL technology that may affect studies in Alzheimer's disease are described. The existing literature describing ASL blood flow imaging applied to Alzheimer's disease and related dementia is reviewed, and the potential role of ASL in treatment and prevention studies of early Alzheimer's disease is discussed.
引用
收藏
页码：871 / 880
页数：10
相关论文
共 71 条
  • [1] Hippocampal hyperperfusion in Alzheimer's disease
    Alsop, David C.
    Casement, Melynda
    de Bazelaire, Cedric
    Fong, Tamara
    Press, Daniel Z.
    [J]. NEUROIMAGE, 2008, 42 (04) : 1267 - 1274
  • [2] Activation and baseline changes in functional MRI studies of Alzheimer disease
    Alsop, David C.
    Press, Daniel Z.
    [J]. NEUROLOGY, 2007, 69 (17) : 1645 - 1646
  • [3] Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow
    Alsop, DC
    Detre, JA
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (06) : 1236 - 1249
  • [4] Alsop DC, 2000, ANN NEUROL, V47, P93, DOI 10.1002/1531-8249(200001)47:1<93::AID-ANA15>3.0.CO
  • [5] 2-8
  • [6] Voxel-based morphometry - The methods
    Ashburner, J
    Friston, KJ
    [J]. NEUROIMAGE, 2000, 11 (06) : 805 - 821
  • [7] Multivariate and univariate analysis of continuous arterial spin labeling perfusion MRI in Alzheimer's disease
    Asllani, Iris
    Habeck, Christian
    Scarmeas, Nikolaos
    Borogovac, Ajna
    Brown, Truman R.
    Stern, Yaakov
    [J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2008, 28 (04) : 725 - 736
  • [8] Validation of Cerebral Blood Perfusion Imaging as a Modality for Quantitative Pharmacological MRI in Rats
    Bruns, Andreas
    Kunnecke, Basil
    Risterucci, Celine
    Moreau, Jean-Luc
    von Kienlin, Markus
    [J]. MAGNETIC RESONANCE IN MEDICINE, 2009, 61 (06) : 1451 - 1458
  • [9] Quantifying CBF with arterial spin labeling
    Buxton, RB
    [J]. JOURNAL OF MAGNETIC RESONANCE IMAGING, 2005, 22 (06) : 723 - 726
  • [10] A general kinetic model for quantitative perfusion imaging with arterial spin labeling
    Buxton, RB
    Frank, LR
    Wong, EC
    Siewert, B
    Warach, S
    Edelman, RR
    [J]. MAGNETIC RESONANCE IN MEDICINE, 1998, 40 (03) : 383 - 396
12345678