Subunit composition of kainate receptors in hippocampal interneurons

被引：172

作者：

Mulle, C ^{[1
]}

Sailer, A

Swanson, GT

Brana, C

O'Gorman, S

Bettler, B

Heinemann, SF

机构：

[1] Univ Bordeaux 2, CNRS, UMR 5091, Inst Francois Magendie, F-33000 Bordeaux, France

[2] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA

[3] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA

来源：

NEURON | 2000年 / 28卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0896-6273(00)00126-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Kainate receptor activation affects GABAergic inhibition in the hippocampus by mechanisms that are thought to involve the GluR5 subunit. We report that disruption of the GluR5 subunit gene does not cause the loss of functional KARs in CA1 interneurons, nor does it prevent kainate-induced inhibition of evoked GABAergic synaptic transmission onto CA1 pyramidal cells. However, KAR function is abolished in mice lacking both GluR5 and GluR6 subunits, indicating that KARs in CA1 stratum radiatum interneurons are heteromeric receptors composed of both subunits. In addition, we show the presence of presynaptic KARs comprising the GluR6 but not the GluR5 subunit that modulate synaptic transmission between inhibitory interneurons. The existence of two separate populations of KARs in hippocampal interneurons adds to the complexity of KAR localization and function.

引用

页码：475 / 484

页数：10

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