Toxicology and Microbiota: How Do Pesticides Influence Gut Microbiota? A Review

被引：74
作者：
Giambo, Federica [1 ]
Teodoro, Michele [1 ]
Costa, Chiara [2 ]
Fenga, Concettina [1 ]
机构：
[1] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Occupat Med Sect, I-98125 Messina, Italy
[2] Univ Messina, Clin & Expt Med Dept, I-98125 Messina, Italy
来源：
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2021年 / 18卷 / 11期
关键词：
gut microbiota; microbial community; pesticides; occupational exposure; dysbiosis; LIPID-METABOLISM DISORDER; ENDOCRINE-DISRUPTING CHEMICALS; SHORT-TERM EXPOSURE; LONG-TERM; OXIDATIVE STRESS; ENVIRONMENTAL TOXICANTS; OCCUPATIONAL-EXPOSURE; GLYPHOSATE EXPOSURE; BARRIER FUNCTION; HOST-RESISTANCE;
D O I：
10.3390/ijerph18115510
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
In recent years, new targets have been included between the health outcomes induced by pesticide exposure. The gastrointestinal tract is a key physical and biological barrier and it represents a primary site of exposure to toxic agents. Recently, the intestinal microbiota has emerged as a notable factor regulating pesticides' toxicity. However, the specific mechanisms related to this interaction are not well known. In this review, we discuss the influence of pesticide exposure on the gut microbiota, discussing the factors influencing gut microbial diversity, and we summarize the updated literature. In conclusion, more studies are needed to clarify the host-microbial relationship concerning pesticide exposure and to define new prevention interventions, such as the identification of biomarkers of mucosal barrier function.
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页数：17
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共 116 条
[81]   Use of a combination of in vitro models to investigate the impact of chlorpyrifos and inulin on the intestinal microbiota and the permeability of the intestinal mucosa [J].
Requile, Marina ;
Alvarez, Duban O. Gonzalez ;
Delanaud, Stephane ;
Rhazi, Larbi ;
Bach, Veronique ;
Depeint, Flore ;
Khorsi-Cauet, Hafida .
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2018, 25 (23) :22529-22540
[82]   Changes in Composition and Function of Human Intestinal Microbiota Exposed to Chlorpyrifos in Oil as Assessed by the SHIME® Model [J].
Reygner, Julie ;
Condette, Claire Joly ;
Bruneau, Aurelia ;
Delanaud, Stephane ;
Rhazi, Larbi ;
Depeint, Flore ;
Abdennebi-Najar, Latifa ;
Bach, Veronique ;
Mayeur, Camille ;
Khorsi-Cauet, Hafida .
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2016, 13 (11)
[83]   The direct and indirect effects of environmental toxicants on the health of bumblebees and their microbiomes [J].
Rothman, Jason A. ;
Russell, Kaleigh A. ;
Leger, Laura ;
McFrederick, Quinn S. ;
Graystock, Peter .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2020, 287 (1937)
[84]   The Honeybee Gut Microbiota Is Altered after Chronic Exposure to Different Families of Insecticides and Infection by Nosema ceranae [J].
Rouze, Regis ;
Mone, Anne ;
Delbac, Frederic ;
Belzunces, Luc ;
Blot, Nicolas .
MICROBES AND ENVIRONMENTS, 2019, 34 (03) :226-233
[85]   Glyphosate-based herbicides influence antioxidants, reproductive hormones and gut microbiome but not reproduction: A long-term experiment in an avian model [J].
Ruuskanen, Suvi ;
Rainio, Miia J. ;
Gomez-Gallego, Carlos ;
Selenius, Otto ;
Salminen, Seppo ;
Collado, Maria Carmen ;
Saikkonen, Kari ;
Saloniemi, Irma ;
Helander, Marjo .
ENVIRONMENTAL POLLUTION, 2020, 266
[86]   Effects of Endocrine-Disrupting Chemicals and Epigenetic Modifications in Ovarian Cancer: A Review [J].
Samtani, Ratika ;
Sharma, Noopur ;
Garg, Deepali .
REPRODUCTIVE SCIENCES, 2018, 25 (01) :7-18
[87]   Revised Estimates for the Number of Human and Bacteria Cells in the Body [J].
Sender, Ron ;
Fuchs, Shai ;
Milo, Ron .
PLOS BIOLOGY, 2016, 14 (08)
[88]   Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice [J].
Smith, Lorraine ;
Klement, Wendy ;
Dopavogui, Leonie ;
de Bock, Frederic ;
Lasserre, Frederic ;
Barretto, Sharon ;
Lukowicz, Celine ;
Fougerat, Anne ;
Polizzi, Arnaud ;
Schaal, Benoist ;
Patris, Bruno ;
Denis, Colette ;
Feuillet, Guylene ;
Canlet, Cecile ;
Jamin, Emilien L. ;
Debrauwer, Laurent ;
Mselli-Lakhal, Laila ;
Loiseau, Nicolas ;
Guillou, Herve ;
Marchi, Nicola ;
Ellero-Simatos, Sandrine ;
Gamet-Payrastre, Laurence .
ENVIRONMENT INTERNATIONAL, 2020, 144
[89]   The Effect of Pesticides on the Microbiome of Animals [J].
Syromyatnikov, Mikhail Y. ;
Isuwa, Mariya M. ;
Savinkova, Olga V. ;
Derevshchikova, Mariya I. ;
Popov, Vasily N. .
AGRICULTURE-BASEL, 2020, 10 (03)
[90]   Diazinon exposure produces histological damage, oxidative stress, immune disorders and gut microbiota dysbiosis in crucian carp (Carassius auratus gibelio) [J].
Tang, Jiali ;
Wang, Wenqian ;
Jiang, Yuanhe ;
Chu, Weihua .
ENVIRONMENTAL POLLUTION, 2021, 269
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