Introduction to the physics of molecular imaging with radioactive tracers in small animals

被引：32

作者：

King, MA ^{[1
]}

Pretorius, PH

Farncombe, T

Beekman, FJ

机构：

[1] Univ Massachusetts, Sch Med, Dept Radiol, Div Nucl Med, Worcester, MA 01655 USA

[2] Univ Utrecht Hosp, Image Sci Inst, Utrecht, Netherlands

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2002年

关键词：

tracers; SPECT; PET; tomography; molecular imaging;

D O I：

10.1002/jcb.10447

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances have greatly enhanced the three-dimensional (3D) imaging of radioactive tracers in living animals. this article introduces the physics of imaging behind the imaging methods. The article first discusses the selection of the radiation emitted from the tracer and then the process of tomographic reconstruction or how 3D images are made from imaging around the outside of the animal. The technique of single photon emission computed tomography (SPECT) in which the detection of one X-ray or gamma ray at a time is employed for image formation is then described, Finally, positron emission tomography (PET) which relies on the simultaneous detection of the pair of gamma-rays formed when the positron annihilates is presented.

引用

页码：221 / 230

页数：10

共 35 条

[11] High resolution PET, SPECT and projection imaging in small animals [J].

Green, MV ;

Seidel, J ;

Vaquero, JJ ;

Lagoda, E ;

Lee, I ;

Eckelman, WC .

COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, 2001, 25 (02) :79-86

[12]

Habraken JBA, 2001, J NUCL MED, V42, P1863

[13] Digital image processing for clinicians, part III: SPELT reconstruction [J].

Hansen, CL .

JOURNAL OF NUCLEAR CARDIOLOGY, 2002, 9 (05) :542-549

[14]

HENDEE WR, 1973, RADIOACTIVE ISOTOPES

[15] Observations on the role of nuclear medicine in molecular imaging [J].

Hnatowich, DJ .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2002, :18-24

[16]

ISHIZU K, 1995, J NUCL MED, V36, P2282

[17] PINHOLE COLLIMATION FOR ULTRA-HIGH-RESOLUTION, SMALL-FIELD-OF-VIEW SPECT [J].

JASZCZAK, RJ ;

LI, JY ;

WANG, HL ;

ZALUTSKY, MR ;

COLEMAN, RE .

PHYSICS IN MEDICINE AND BIOLOGY, 1994, 39 (03) :425-437

[18] A 3D HIDAC-PET camera with sub-millimetre resolution for imaging small animals [J].

Jeavons, AP ;

Chandler, RA ;

Dettmar, CAR .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1999, 46 (03) :468-473

[19] Gamma-ray imaging using a CdZnTe pixel array and a high-resolution, parallel-hole collimator [J].

Kastis, GA ;

Barber, HB ;

Barrett, HH ;

Balzer, SJ ;

Lu, D ;

Marks, DG ;

Stevenson, G ;

Woolfenden, JM ;

Appleby, M ;

Tueller, J .

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2000, 47 (06) :1923-1927

[20]

KING MA, 2003, EMISSION TOMOGRAPHY

← 1 2 3 4 →