Estrogens maintain skeletal muscle and satellite cell functions

被引:108
作者
Kitajima, Yuriko [1 ]
Ono, Yusuke [1 ]
机构
[1] Nagasaki Univ, Atom Bomb Dis Inst, Dept Stem Cell Biol, Grad Sch Biomed Sci, Nagasaki, Japan
基金
日本科学技术振兴机构; 日本学术振兴会;
关键词
estrogens; skeletal muscle; muscle atrophy; satellite cells; females; FIBER-TYPE SPECIFICITY; LIMB MUSCLE; MALE RATS; KAPPA-B; MASS; ATROPHY; MICE; ACTIVATION; REGENERATION; OVARIECTOMY;
D O I
10.1530/JOE-15-0476
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Estrogens have crucial roles in an extensive range of physiological functions regulating cellular proliferation and differentiation, development, homeostasis, and metabolism. Therefore, prolonged estrogen insufficiency influences various types of tissues expressing estrogen receptors (ERs). Although ERs are expressed in skeletal muscle and its stem cells, called satellite cells, how prolonged estrogen insufficiency affects their function remains unclear. In this study, we investigated the effect of estrogen reduction on muscle in young ovariectomized (OVX) female mice. We found that reduced estrogens resulted in muscle atrophy in a time-dependent manner. Muscle force generation was reduced in OVX mice. Interestingly, prolonged estrogen insufficiency shifted fiber types toward faster myosin heavy chain isoforms. The number of satellite cells per isolated myofiber was unchanged, while satellite cell expansion, differentiation, and self-renewal were all markedly impaired in OVX mice. Indeed, muscle regeneration was significantly compromised in OVX mice. Taken together, our results demonstrate that estrogens are essential for comprehensively maintaining muscle function with its insufficiency affecting muscle strength and regeneration in young female mice.
引用
收藏
页码:267 / 275
页数:9
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