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Aliphatic acetylenic homocoupling catalyzed by a novel combination of AgOTs-CuCl2-TMEDA and its application for the solid-phase synthesis of bis-benzo[b]furan-linked 1,3-diynes
被引：68
|作者：
Liao, Y
Fathi, R
Yang, Z
机构：
[1] VivoQuest Inc, New York, NY 10989 USA
[2] Peking Univ, Coll Chem, Dept Biol Chem, Minist Educ,Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
关键词：
D O I：
10.1021/ol030009g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ;
081704 ;
摘要：
A novel catalytic system of AgOTs-CuCl2-TMEDA is described for the homocoupling of aliphatic acetylenes on solid support. It is the first observation that Ag-l's activating triple bond could facilitate Cu-II-mediated oxidative acetylenic homocoupling. This study provides an efficient way to synthesize a diversified symmetrical bis-benzo[b]furan-linked 1,3-diyne library on solid support.
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页码：909 / 912
页数：4
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