mPGES-1 DELETION INCREASES PROSTACYCLIN AND EVADES THE ELEVATED SYSTEMIC ADMA ASSOCIATED WITH COX-2 INHIBITORS: RELEVANCE TO CARDIOVASCULAR SAFETY OF mPGES-1 INHIBITORS

被引：4
|
作者：
Raouf, J. [2 ]
Kirkby, N. S. [1 ]
Ahmetaj-Shala, B. [1 ]
Liu, B. [3 ]
Mazi, S. I. [1 ]
Korotkova, M. [2 ]
Zhou, Y. [3 ]
Mitchell, J. A. [1 ]
Jakobsson, P. J. [2 ]
机构：
[1] Imperial Coll London, Natl Heart & Lung Inst, Vasc Biol Sect, London, England
[2] Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden
[3] Shantou Univ, Coll Med, Cardiovasc Res Ctr, Shantou, Peoples R China
来源：
ANNALS OF THE RHEUMATIC DISEASES | 2016年 / 75卷
关键词：
D O I：
10.1136/annrheumdis-2016-209124.27
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A1.27
引用
收藏
页码：A11 / +
页数：2
相关论文
共 50 条
  • [1] mPGES-1 deletion increases prostacyclin and evades the elevated systemic ADMA associatedwith COX-2 inhibitors: relevance to cardiovascular safety of mPGES-1 inhibitors
    Raouf, J.
    Kirkby, N.
    Ahmetaj-Shala, B.
    Liu, B.
    MRes, S. M.
    Korotkova, M.
    Zeldin, D.
    Zhou, Y.
    Jakobsson, P-J
    Mitchell, J.
    SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2016, 45 : 24 - 25
  • [2] Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis
    Kirkby, Nicholas S.
    Raouf, Joan
    Ahmetaj-Shala, Blerina
    Liu, Bin
    Mazi, Sarah, I
    Edin, Matthew L.
    Chambers, Mark Geoffrey
    Korotkova, Marina
    Wang, Xiaomeng
    Wahli, Walter
    Zeldin, Darryl C.
    Nusing, Rolf
    Zhou, Yingbi
    Jakobsson, Per-Johan
    Mitchell, Jane A.
    CARDIOVASCULAR RESEARCH, 2020, 116 (12) : 1972 - 1980
  • [3] COX-2 and mPGES-1 derived eicosanoids and cardiovascular function
    Fitzgerald, GA
    Wang, M
    Cheng, Y
    Yi, Y
    Lawson, J
    Funk, C
    PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2006, 79 (1-2) : 157 - 157
  • [4] Novel benzoxazole inhibitors of mPGES-1
    Kablaoui, Natasha
    Patel, Snahel
    Shao, Jay
    Demian, Douglas
    Hoffmaster, Keith
    Berlioz, Francioise
    Vazquez, Michael L.
    Moore, William M.
    Nugent, Richard A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (03) : 907 - 911
  • [5] mPGES-1 inhibitors from start to clinic
    Schiffler, Matthew
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [6] Trisubstituted ureas as potent and selective mPGES-1 inhibitors
    Chiasson, Jean-Francois
    Boulet, Louise
    Brideau, Christine
    Chau, Anh
    Claveau, David
    Cote, Bernard
    Ethier, Diane
    Giroux, Andre
    Guay, Jocelyne
    Guiral, Sebastien
    Mancini, Joseph
    Masse, Frederic
    Methot, Nathalie
    Riendeau, Denis
    Roy, Patrick
    Rubin, Joel
    Xu, Daigen
    Yu, Hongping
    Ducharme, Yves
    Friesen, Richard W.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (05) : 1488 - 1492
  • [7] Identification and development of mPGES-1 inhibitors: where we are at?
    Chang, Hui-Hua
    Meuillet, Emmanuelle J.
    FUTURE MEDICINAL CHEMISTRY, 2011, 3 (15) : 1909 - 1934
  • [8] Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
    H Takeda
    H Miyoshi
    Y Tamai
    M Oshima
    M M Taketo
    British Journal of Cancer, 2004, 90 : 701 - 704
  • [9] ROLE OF COX-2/MPGES-1 AXIS ON VASCULAR REMODELING IN HYPERTENSION
    Avendano, M. S.
    Martinez-Revelles, S.
    Aguado, A.
    Simoes, M. R.
    Aras-Lopez, R.
    Iniguez, M. A.
    Cachofeiro, M., V
    Vila, L.
    Camacho, M.
    Salaices, M.
    Briones, A. M.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 115 : 29 - 29
  • [10] Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
    Takeda, H
    Miyoshi, H
    Tamai, Y
    Oshima, M
    Taketo, MM
    BRITISH JOURNAL OF CANCER, 2004, 90 (03) : 701 - 704
12345