ACE and ACTN3 Genes and Muscle Phenotypes in Nonagenarians

被引：36

作者：

Bustamante-Ara, N. ^{[1
]}

Santiago, C. ^{[1
]}

Verde, Z. ^{[1
]}

Yvert, T. ^{[1
]}

Gomez-Gallego, F. ^{[1
]}

Rodriguez-Romo, G. ^{[2
]}

Gonzalez-Gil, P. ^{[3
]}

Serra-Rexach, J. A. ^{[4
]}

Ruiz, J. R. ^{[5
]}

Lucia, A. ^{[1
]}

机构：

[1] Univ Europea Madrid, Madrid 28670, Spain

[2] Univ Politecn Madrid, INEF, Madrid, Spain

[3] Residencia Los Nogales Pacifico, Dept Med, Madrid, Spain

[4] Hosp Gen Gregorio Maranon, Madrid, Spain

[5] Karolinska Inst, Dpt Biosci & Nutr, Unit Prevent Nutr, Huddinge, Sweden

来源：

INTERNATIONAL JOURNAL OF SPORTS MEDICINE | 2010年 / 31卷 / 04期

关键词：

nonagenarians; muscular strength; ACE genotype; ACTN3; genotype; CONVERTING-ENZYME GENE; ENDURANCE PERFORMANCE; ID GENOTYPE; STRENGTH; WOMEN; POLYMORPHISM; EXERCISE; MEN; DEFICIENCY; DISEASE;

D O I：

10.1055/s-0030-1247529

中图分类号：

G8 [体育];

学科分类号：

04 ; 0403 ;

摘要：

We studied the association of ACE and ACTN3 polymorphisms with skeletal muscle phenotypes (i.e. upper and lower body muscular strength and functional tests) in Spanish nonagenarian subjects [n =41, 33 women, 8 men, age: 90-97 years]. Mean values of the study phenotypes were not significantly different (all P>0.05) between ACE and ACTN3 genotypes. The analyses of the combined effects between genotypes (ACE DD & ACTN3 RR/RX vs. ACE II/ID & ACTN3 XX) did not yield any significant difference. Our data suggest that, in the elderly, the influence of genetic factors on muscle phenotype traits is not reducible to a few single polymorphisms, including ACE and ACTN3 variants.

引用

页码：221 / 224

页数：4

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