Recent advances in chemical synthesis, biocatalysis, and biological evaluation of diosgenin derivatives - A review

被引:15
作者
Fan, Ruolan [1 ]
He, Weishen [2 ]
Fan, Yong [1 ]
Xu, Wen [1 ]
Xu, Wei [1 ]
Yan, Guohong [3 ]
Xu, Shaohua [1 ]
机构
[1] Fujian Univ Tradit Chinese Med, Coll Pharm, 1 Qiuyang Rd, Fuzhou 350122, Fujian, Peoples R China
[2] Boston Coll, Biol Dept, Brighton, MA 02135 USA
[3] Fujian Univ Tradit Chines, Pharm Dept, Peoples Hosp, 602 817 Middle Rd, Fuzhou 350004, Fujian, Peoples R China
关键词
Diosgenin; Derivatives; Chemical modification; Biotransformation; MICROBIAL TRANSFORMATION; FILAMENTOUS FUNGUS; CUNNINGHAMELLA; DESIGN; GLYCOSYLATION; SOLUBILITY; CONVERSION; CELLS;
D O I
10.1016/j.steroids.2022.108991
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Extracting organic compounds from plants and developing derivatives are essential methods for drug discovery. Diosgenin, extracted from Dioscoreaceae plants, is a type of spirostan steroid with various biological effects, including anti-inflammation, neuro-protection, and apoptosis-induction. Many researchers committed their work to the chemical semi-synthesis of diosgenin derivatives to improve diosgenin's therapeutic bioavailability and expand its range of applications in disease treatment and prevention. Biotransformation, a mild whole-cell biocatalysis method, also made crucial contributions to the structural diversity of diosgenin analogs in recent years. Although the structural modification of diosgenin has made significant progress, it lacks a comprehensive review. Here, we review the chemical modification and biotransformation of diosgenin along with the biological evaluation of diosgenin derivatives to provide a reference for the structural modification strategy and pharmaceutical application of diosgenin derivatives.
引用
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页数:27
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