Vascular Responses to Hypoxia and Ischemia

被引：129

作者：

Semenza, Gregg L. ^{[1
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机构：

[1] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD USA

[5] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Vasc Program, Inst Cell Engn, Baltimore, MD USA

[7] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Baltimore, MD USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2010年 / 30卷 / 04期

基金：

美国国家卫生研究院;

关键词：

angiogenesis; gene therapy; ischemic biology; hypoxia; ischemia; INDUCIBLE FACTOR-I; ENDOTHELIAL GROWTH-FACTOR; AGE-DEPENDENT IMPAIRMENT; MYOCARDIAL-INFARCTION; TRANSCRIPTION FACTOR; LIMB ISCHEMIA; RETINAL NEOVASCULARIZATION; EARLY EXPRESSION; GENE-EXPRESSION; DIABETIC MICE;

D O I：

10.1161/ATVBAHA.108.181644

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blood vessels function as conduits for the delivery of O-2 and nutrients. Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia that include expression of angiogenic cytokines/growth factors by hypoxic cells and expression of cognate receptors for these ligands by vascular cells and their progenitors. Impairment of HIF-1-dependent responses to hypoxia is a major factor contributing to the impaired vascular responses to ischemia that are associated with aging and diabetes. (Arterioscler Thromb Vasc Biol. 2010; 30: 648-652.)

引用

页码：648 / 652

页数：5

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