A traceless solid-supported synthesis of novel pyrazinediazepinedione derivatives

被引：9
作者：
Mieczkowski, Adam [1 ]
Jurczak, Janusz [1 ,2 ]
机构：
[1] Warsaw Univ, Dept Chem, PL-02093 Warsaw, Poland
[2] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland
来源：
TETRAHEDRON | 2010年 / 66卷 / 13期
关键词：
VASOPRESSIN RECEPTOR ANTAGONISTS; BETA-TURN MIMETICS; DESIGN;
D O I：
10.1016/j.tet.2010.01.064
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, convenient, six-step synthesis of novel, tricyclic pyrazinebenzodiazepinedione derivatives has been described. The strategy is based on the use of the orthogonally-protected, optically pure, (S)-piperazine-2-carboxylic acid, in a Petasis reaction, followed by coupling with anthranilic acid and finally cyclizing cleavage. The investigated method was applied for the synthesis of novel bicyclic pyrazinediaze-pinedione derivatives. This traceless, solid-supported approach allows the preparation of a wide variety of compounds in moderate yields from commercially available or easily obtainable reagents. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2514 / 2519
页数：6
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