How to control lymphangiogenesis: A novel role for rapamycin

被引：13

作者：

Kerjaschki, D. ^{[1
]}

机构：

[1] Univ Vienna, Allgemeines Krankenhaus, Dept Pathol, A-1090 Vienna, Austria

来源：

KIDNEY INTERNATIONAL | 2007年 / 71卷 / 08期

关键词：

D O I：

10.1038/sj.ki.5002184

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Analysis of the lymphatic microvasculature has become possible only recently by the discovery of novel proteins specifically expressed in lymphatic endothelial cells only. Therapeutic manipulation of de novo lymphangiogenesis might become clinically relevant in the future in diverse situations, such as renal transplant rejection. In this issue Huber et al. demonstrate that rapamycin acts as an efficient inhibitor of lymphangiogenesis.

引用

页码：717 / 719

页数：3

共 13 条

[1] Molecular mechanisms of lymphangiogenesis in health and disease
Alitalo, K
Carmeliet, P
[J]. CANCER CELL, 2002, 1 (03) : 219 - 227
[2] Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents
Holash, Jocelyn
Thurston, Gavin
Rudge, John S.
Yancopoulos, George D.
Adjei, Alex A.
Bergers, Gabriele
Pytowski, Bronislaw
Pegram, Mark
Gordon, Michael S.
[J]. CANCER AND METASTASIS REVIEWS, 2006, 25 (02) : 243 - 252
[3] Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis
Huber, S.
Bruns, C. J.
Schmid, G.
Hermann, P. C.
Conrad, C.
Niess, H.
Huss, R.
Graeb, C.
Jauch, K-W
Heeschen, C.
Guba, M.
[J]. KIDNEY INTERNATIONAL, 2007, 71 (08) : 771 - 777
[4] Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
Jeltsch, M
Kaipainen, A
Joukov, V
Meng, XJ
Lakso, M
Rauvala, H
Swartz, M
Fukumura, D
Jain, RK
Alitalo, K
[J]. SCIENCE, 1997, 276 (5317) : 1423 - 1425
[5] Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates
Kerjaschki, D
Regele, HM
Moosberger, I
Nagy-Bojarski, K
Watschinger, B
Soleiman, A
Birner, P
Krieger, S
Hovorka, A
Silberhumer, G
Laakkonen, P
Petrova, T
Langer, B
Raab, I
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2004, 15 (03): : 603 - 612
[6] Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants
Kerjaschki, D
Huttary, N
Raab, I
Regele, H
Bojarski-Nagy, K
Bartel, G
Kröber, SM
Greinix, H
Rosenmaier, A
Karlhofer, F
Wick, N
Mazal, PR
[J]. NATURE MEDICINE, 2006, 12 (02) : 230 - 234
[7] Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
Kriehuber, E
Breiteneder-Geleff, S
Groeger, M
Soleiman, A
Schoppmann, SF
Stingl, G
Kerjaschki, D
Maurer, D
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (06) : 797 - 808
[8] Inflammation-induced lymphangiogenesis in the cornea arises from CD11 b-positive macrophages
Maruyama, K
Li, M
Cursiefen, C
Jackson, DG
Keino, H
Tomita, M
Van Rooijen, N
Takenaka, H
D'Amore, PA
Stein-Streilein, J
Losordo, DW
Streilein, JW
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (09) : 2363 - 2372
[9] Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase P and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels
Matsui, K
Nagy-Bojarsky, K
Laakkonen, P
Krieger, S
Mechtler, K
Uchida, S
Geleff, S
Kang, DH
Johnson, RJ
Kerjaschki, D
[J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2003, 14 (08): : 1981 - 1989
[10] Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis
Schoppmann, SF
Birner, P
Stöckl, J
Kalt, R
Ullrich, R
Caucig, C
Kriehuber, E
Nagy, K
Alitalo, K
Kerjaschki, D
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (03) : 947 - 956

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