Voxel-based assessment of gray and white matter volumes in Alzheimer's disease

被引：116

作者：

Guo, Xiaojuan ^{[1
,2
]}

Wang, Zhiqun ^{[3
]}

Li, Kuncheng ^{[3
]}

Li, Ziyi ^{[1
]}

Qi, Zhigang ^{[3
]}

Jin, Zhen ^{[4
]}

Yao, Li ^{[1
,2
]}

Chen, Kewei ^{[5
,6
]}

机构：

[1] Beijing Normal Univ, Coll Informat Sci & Technol, Beijing 100875, Peoples R China

[2] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China

[3] Xuanwu Hosp Capital Med Univ, Dept Radiol, Beijing, Peoples R China

[4] Beijing 306 Hosp, Lab Magnet Resonance Imaging, Beijing, Peoples R China

[5] Banner Alzheimers Inst, 1111 McDowell Rd, Phoenix, AZ 85006 USA

[6] Banner Good Samaritan PET Ctr, 1111 McDowell Rd, Phoenix, AZ 85006 USA

来源：

NEUROSCIENCE LETTERS | 2010年 / 468卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; Gray matter; Magnetic resonance imaging; Voxel-based morphometry; White matter; CORPUS-CALLOSUM; ATROPHY; MORPHOMETRY; BRAIN; ABNORMALITIES; REDUCTION;

D O I：

10.1016/j.neulet.2009.10.086

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the study-specific templates and optimized voxel-based morphometry (VBM), this study investigated abnormalities in gray and white matter to provide depiction of the concurrent structural changes in 13 patients with Alzheimer's disease (AD) compared with 14 age- and sex-matched normal controls. Consistent with previous studies, patients with AD exhibited significant gray matter volume reductions mainly in the hippocampus, parahippocampal gyrus, insula, superior/middle temporal gyrus, thalamus, cingulate gyrus, and superior/inferior parietal lobule. In addition, white matter volume reductions were found predominately in the temporal lobe, corpus callosum, and inferior longitudinal fasciculus. Furthermore, a number of additional white matter regions such as precentral gyrus, cingulate fasciculus, superior and inferior frontal gyrus, and sub-gyral in parietal lobe were also affected. The pattern of gray and white matter volume reductions helps us understand the underlying pathologic mechanisms in AD and potentially can be used as an imaging marker for the studies of AD in the future. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：146 / 150

页数：5

共 25 条

[1] Voxel-based morphometry - The methods [J].

Ashburner, J ;

Friston, KJ .

NEUROIMAGE, 2000, 11 (06) :805-821

[2]

Baxter LC, 2006, J ALZHEIMERS DIS, V9, P253

[3] Volumetric reduction of the corpus callosum in Alzheimer's disease in vivo as assessed with voxel-based morphometry [J].

Chaim, Tiffany M. ;

Duran, Fabio L. S. ;

Uchida, Ricardo R. ;

Perico, Cintia A. M. ;

de Castro, Claudio C. ;

Busatto, Geraldo F. .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2007, 154 (01) :59-68

[4] Linking functional and structural brain images with multivariate network analyses: A novel application of the partial least square method [J].

Chen, Kewei ;

Reiman, Eric M. ;

Huan, Zhongdan ;

Caselli, Richard J. ;

Bandy, Daniel ;

Ayutyanont, Napatkamon ;

Alexander, Gene E. .

NEUROIMAGE, 2009, 47 (02) :602-610

[5] An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients with probable Alzheimer's disease [J].

Chen, KW ;

Reiman, EM ;

Alexander, GE ;

Bandy, D ;

Renaut, R ;

Crum, WR ;

Fox, NC ;

Rossor, MN .

NEUROIMAGE, 2004, 22 (01) :134-143

[6] Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI:: A longitudinal MRI study [J].

Chételat, G ;

Landeau, B ;

Eustache, F ;

Mézenge, F ;

Viader, F ;

de la Sayette, V ;

Desgranges, B ;

Baron, JC .

NEUROIMAGE, 2005, 27 (04) :934-946

[7]

FAZEKAS F, 1987, AM J NEURORADIOL, V8, P421

[8] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[9] A voxel-based morphometric study of ageing in 465 normal adult human brains [J].

Good, CD ;

Johnsrude, IS ;

Ashburner, J ;

Henson, RNA ;

Friston, KJ ;

Frackowiak, RSJ .

NEUROIMAGE, 2001, 14 (01) :21-36

[10] Automatic differentiation of anatomical patterns in the human brain: Validation with studies of degenerative dementias [J].

Good, CD ;

Scahill, RI ;

Fox, NC ;

Ashburner, J ;

Friston, KJ ;

Chan, D ;

Crum, WR ;

Rossor, MN ;

Frackowiak, RSJ .

NEUROIMAGE, 2002, 17 (01) :29-46

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