Screening for Oral Cancer Using Electrochemical Telomerase Assay

被引：12

作者：

Hayakawa, Mana ^{[1
]}

Sato, Shinobu ^{[2
]}

Diala, Irmina ^{[2
]}

Kodama, Masaaki ^{[1
]}

Tomoeda-Mori, Kumiko ^{[3
]}

Haraguchi, Kazuya ^{[1
]}

Tominaga, Kazuhiro ^{[1
]}

Takenaka, Shigeori ^{[2
]}

机构：

[1] Kyushu Dent Univ, Div Oral & Maxillofacial Surg, Dept Sci Phys Funct, Fukuoka, Japan

[2] Kyushu Inst Technol, Dept Appl Chem, Fukuoka, Japan

[3] Natl Hosp Org Kumamoto Med, Dept Oral & Maxillofacial Surg, Kumamoto, Japan

来源：

ELECTROANALYSIS | 2016年 / 28卷 / 03期

关键词：

telomerase; hTERT gene; oral cancer screening; electrochemical assay; SQUAMOUS-CELL CARCINOMA; LESIONS; DIIMIDE; HEAD; DNA; EXPRESSION; DIAGNOSIS;

D O I：

10.1002/elan.201500426

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Electrochemical telomerase assay (ECTA) developed by our group was evaluated in an oral cancer screening using exfoliated oral cells and tissues obtained from patients of oral cancer, mucosa associated disease, or healthy volunteers. Telomerase activity from ECTA is correlated with hTERT mRNA expression level using a real-time PCR and was increasing in the following order: healthy volunteer group<mucosa associated disease group<oral cancer group. Sensitivity and specificity of ECTA were 88% and 72%, respectively when used 17% of the threshold value based on the receiver operating characteristic curve in ECTA data.

引用

页码：503 / 507

页数：5

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