Lack of mutations of BCL6 and BCL10 genes in mucosa-associated lymphoid tissue lymphomas of the orbital adnexa

被引：6

作者：

Chen, PM

Liu, JH

Yu, IT

Kao, SC

Lin, YC

Chiang, H

Fan, FS

Chiou, TJ

Wang, WS

Yen, CC ^{[1
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Med, Sect Med Oncol, Taipei, Taiwan

[2] Natl Yang Ming Univ, Taipei 112, Taiwan

[3] Taipei Vet Gen Hosp, Dept Pathol, Sect Med Oncol, Taipei, Taiwan

[4] Taipei Vet Gen Hosp, Dept Ophthalmol, Sect Med Oncol, Taipei, Taiwan

来源：

CANCER GENETICS AND CYTOGENETICS | 2000年 / 123卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(00)00298-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Knowledge regarding the molecular pathogenesis and progression of mucosa-associated lymphoid tissue (MALT) lymphomas of ocular adnexa is limited. Eleven cases of ocular MALT lymphoma were analyzed by clonal rearrangement of antigen receptor genes using Southern blot hybridization. Polymerase chain reaction-single stranded conformational polymorphism analysis and DNA sequencing was utilized to analyze the mutations of BCL6 and BCL10 genes. Clonal rearrangement of immunoglobulin heavy genes was found in all 11 patients. No point mutation was round in BCL6 or BCL10 genes in any of the samples analyzed. We suggest that mutations of BCL6; and BCL10 genes are rare: in low-grade MALT lymphoma of ocular adnexa and are unlikely to be involved in the pathogenesis of the disease. But the role of alterations of both BCL6 and BCL10 genes in the disease progression of low-grade MALT lymphoma require additional study. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：44 / 48

页数：5

共 26 条

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