Association between irisin and homocysteine in euglycemic and diabetic subjects

被引:36
作者
Alis, Rafael [1 ,2 ]
Sanchis-Gomar, Fabian [3 ,4 ]
Pareja-Galeano, Helios [3 ,4 ]
Hernandez-Mijares, Antonio [4 ,5 ,6 ,7 ]
Romagnoli, Marco [8 ]
Victor, Victor M. [1 ,3 ,4 ,5 ,6 ]
Rocha, Milagros [4 ,5 ,6 ]
机构
[1] Catholic Univ Valencia San Vicente Martir, Res Univ Inst Dr Vina Giner, Valencia, Spain
[2] Catholic Univ Valencia San Vicente Martir, Fac Med, Valencia, Spain
[3] Univ Valencia, Fac Med, Dept Physiol, E-46003 Valencia, Spain
[4] Inst Hlth Res INCLIVA, Valencia, Spain
[5] Univ Hosp Doctor Peset, Serv Endocrinol, Valencia 46017, Spain
[6] Valencian Community FISABIO, Fdn Promot Healthcare & Biomed Res, Valencia, Spain
[7] Univ Valencia, Fac Med, Dept Med, E-46003 Valencia, Spain
[8] Catholic Univ Valencia San Vicente Martir, Dept Phys Educ & Sports, Valencia, Spain
关键词
Irisin; Homocysteine; Cardiovascular risk factors; Nicotinamide; Myokine;
D O I
10.1016/j.clinbiochem.2014.08.017
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objectives: The aim of study was to explore whether a relationship exists between homocysteine and irisin in type 2 diabetes (T2D) patients-a population with a high risk of developing cardiovascular disease-and euglycemic controls. Design and methods: 69 T2D patients and 75 control subjects (adjusted by body mass index (BMI)) were included in the study. Irisin and homocysteine concentrations and anthropometric and biochemical variables were determined. Results: Levels of homocysteine were significantly higher (11.0 +/- 3.0 vs 12.4 +/- 4.2 mu mol/l) and levels of irisin were lower (279 +/- 58 vs 263 +/- 38 ng/ml) in T2D patients. When both T2D and controls were considered, irisin was found to correlate only with homocysteine (r = -0.215; p = 0.011). Moreover, a decreasing trend in irisin levels was observed according to homocysteine tertile (p = 0.034). Conclusions: Our results provide evidence of an association between irisin and homocysteine, which may be due to nicotinamide metabolism. The clinical significance of this relationship is unclear, but our findings may prompt further mechanistic research to investigate the role played by irisin in vascular disorders. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:333 / 335
页数:3
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