Improved, efficient synthesis for multigram-scale production of PSB-10, a potent antagonist at human A3 adenosine receptors

被引：0

作者：

Burbiel, J ^{[1
]}

Thorand, M ^{[1
]}

Müller, CE ^{[1
]}

机构：

[1] Univ Bonn, Inst Pharmazeut, D-53115 Bonn, Germany

来源：

HETEROCYCLES | 2003年 / 60卷 / 06期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reported synthesis of PSB-10 (8-ethyl-4-methyl-2-(2,3,5-trichlorophenyl)-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]purin-5-one), a potent A(3)-selective adenosine receptor antagonist, gives only moderate yields and is not suitable for the production of PSB-10 on a multi-gram scale. Attempts to develop alternative routes and an improved procedure suitable for preparing large quantities of PSB-10, required for pharmacological studies, are described.

引用

页码：1425 / 1432

页数：8

共 29 条

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