Morphologic Corneal Changes after Crosslinking for Keratoconus

被引：5

作者：

Mueller, P. L. ^{[1
,2
]}

Loeffler, K. U. ^{[1
,2
]}

Kohlhaas, M. ^{[3
]}

Holz, F. G. ^{[1
]}

Herwig-Carl, M. C. ^{[1
,2
]}

机构：

[1] Univ Augenklin Bonn, Ernst Abbe Str 2, D-53127 Bonn, Germany

[2] Univ Augenklin Bonn, Sekt Ophthalmopathol, Bonn, Germany

[3] St Johannes Hosp, Augenklin, Dortmund, Germany

来源：

KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE | 2018年 / 235卷 / 07期

关键词：

crosslinking; ophthalmic pathology; keratoconus; VIVO CONFOCAL MICROSCOPY; LIMBAL EPITHELIAL-CELLS; PROGRESSIVE KERATOCONUS; ULTRAVIOLET-A; RIBOFLAVIN-ULTRAVIOLET; BIOMECHANICAL PROPERTIES; DEMARCATION LINE; UVA-LIGHT; COLLAGEN; KERATITIS;

D O I：

10.1055/s-0043-102577

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Keratoconus is a relatively common (1:2000) bilateral disease leading to a change in biochemical and biomechanical corneal structure as well as thinning and ectasia. For more than 10 years, crosslinking has been a therapeutic option in cases of progression. Using riboflavin and UVA-radiation, the anterior corneal stroma (300 mu m) gets stiffened by crosslinking of collagen fibers. When protocols and limitations are adhered, the procedure is described to be effective and of low-risk. This review gives an overview about physiologic and pathologic changes in keratoconic corneas before and after crosslinking. Based on histopathologic examination, the current knowledge in published literature is reviewed and is complemented by our own investigations.

引用

页码：809 / 819

页数：11

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