Chromosome instability and progression in urothelial cell carcinoma of the bladder

被引:6
|
作者
Santos, L
Pereira, S
Leite, RP
Souto, M
Amaro, T
Criado, B
机构
[1] Inst Portugues Oncol Francisco Gentil, Dept Surg Oncol, PT-4200 Oporto, Portugal
[2] Inst Portugues Oncol Francisco Gentil, Mol Oncol Unit, PT-4200 Oporto, Portugal
[3] Inst Portugues Oncol Francisco Gentil, Dept Pathol, PT-4200 Oporto, Portugal
[4] Vila Real Peso Regua Hosp, Genet Unit, Vila Real, Portugal
[5] Polytech Inst Hlth N B Criado, Gandra, Portugal
关键词
D O I
10.1080/02841860310005048
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Superficial urothelial cell carcinoma (UCC) is a heterogeneous group of neoplasia With an unpredictable clinical course. Numerical alterations of chromosomes 7, 9 and 17 in superficial and invasive UCCs were analysed to evaluate the importance of chromosome instability in the progression of these tumours. Our sample consisted of 75 patients (47 with superficial and 28 with invasive bladder tumours. In situ hybridization using, centromeric probes for chromosomes 7, 9 and 17 was done for the chromosome analysis in paraffin-embedded tissues. From the results obtained it can be concluded that losses of genetic material seem to be important early events in the carcinogenesis of the urothelium, but during progression of UCCs there seems to be a selection of those cells with gains of genetic material. This chromosome instability may be due to the acquisition of mechanisms involved in aneuploidization, namely p53 function disorders.
引用
收藏
页码:169 / 173
页数:5
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