The transcriptional repression of platelet-derived growth factor receptor-13 by the zinc finger transcription factor ZNF24

被引：10

作者：

Li, Jianzhong ^{[1
]}

Chen, Xia ^{[2
]}

Liu, Ying ^{[1
]}

Ding, Li ^{[1
]}

Qiu, Lei ^{[1
]}

Hu, Zhenlin ^{[1
]}

Zhang, Junping ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Biochem Pharm, Shanghai, Peoples R China

[2] Second Mil Med Univ, Inst Canc, Shanghai, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 397卷 / 02期

基金：

中国国家自然科学基金;

关键词：

ZNF24; PDGFR-beta; c-Myc; Transcriptional repression; FACTOR-BETA-RECEPTOR; C-MYC; NF-Y; COLORECTAL ADENOCARCINOMA; TUMOR VASCULATURE; BREAST-CARCINOMA; STROMAL CELLS; EXPRESSION; CANCER; DOMAIN;

D O I：

10.1016/j.bbrc.2010.05.110

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The zinc finger transcription factor ZNF24 is a relatively uncharacterized Kruppel-like transcription factor, displaying a suppressive effect on the transcription. ZNF24 is involved in negative regulation of vascular endothelial growth factor (VEGF) and may represent a novel repressor of VEGF transcription. In a previous study, our analysis reveals that ZNF24 is a pleiotropic factor that has a role in hematopoiesis, brain development and cancers. Activation of PDGFR-beta is critically involved into various cell functions including recruitment of stromal cells and VEGF induction in tumor and perivascular cells. Here, overexpression of ZNF24 resulted in a significant down-regulation of PDGFR-beta, whereas silencing of ZNF24 with small interfering RNA led to increased PDGFR-beta expression. Overexpression of ZNF24 resulted in a significant decrease in PDGFR-beta promoter activity. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription. Crown Copyright (C) 2010 Published by Elsevier Inc. All rights reserved.

引用

页码：318 / 322

页数：5

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