Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis

被引：42

作者：

Zhao, Lina ^{[1
]}

Gao, Yanxia ^{[2
]}

Guo, Shigong ^{[3
]}

Lu, Xin ^{[1
]}

Yu, Shiyuan ^{[1
]}

Ge, Zeng Zheng ^{[1
]}

Zhu, Hua Dong ^{[1
]}

Li, Yi ^{[1
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Emergency Dept, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China

[2] Zhengzhou Univ, Affiliated Hosp 1, Emergency Dept, Zhengzhou, Peoples R China

[3] Southmead Hosp, Dept Rehabil Med, Bristol, Avon, England

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2021年 / 20卷 / 02期

关键词：

Hyperammonemia; intestinal flora imbalance; inflammatory medium; neurotransmitters; sepsis-associated encephalopathy; mitochondrial dysfunction; BLOOD-BRAIN-BARRIER; GUT MICROBIOTA; COGNITIVE IMPAIRMENT; GLUTAMINE-SYNTHETASE; SYSTEMIC INFECTION; AMINO-ACIDS; RAT-BRAIN; ACTIVATION; INFLAMMATION; EXPRESSION;

D O I：

10.2174/1871527319999201117122158

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies.

引用

页码：112 / 124

页数：13

共 113 条

[1] Structure and function of the blood-brain barrier [J].

Abbott, N. Joan ;

Patabendige, Adjanie A. K. ;

Dolman, Diana E. M. ;

Yusof, Siti R. ;

Begley, David J. .

NEUROBIOLOGY OF DISEASE, 2010, 37 (01) :13-25

[2]

[Anonymous], 2015, CURR HEPATOL REP, DOI DOI 10.1007/S11901-015-0252-Z

[3] Increasing plasma neopterin and persistent plasma endothelin during follow-up after acute cerebral ischemia [J].

Anwaar, I ;

Gottsäter, A ;

Lindgärde, F ;

Mattiasson, I .

ANGIOLOGY, 1999, 50 (01) :1-8

[4] The microbiome as a key regulator of brain, behavior and immunity: Commentary on the 2017 named series [J].

Bailey, Michael T. ;

Cryan, John F. .

BRAIN BEHAVIOR AND IMMUNITY, 2017, 66 :18-22

[5] Amino acid imbalance early in septic encephalopathy [J].

Basler, T ;

Meier-Hellmann, A ;

Bredle, D ;

Reinhart, K .

INTENSIVE CARE MEDICINE, 2002, 28 (03) :293-298

[6] Microglia-mediated neurotoxicity: uncovering the molecular mechanisms [J].

Block, Michelle L. ;

Zecca, Luigi ;

Hong, Jau-Shyong .

NATURE REVIEWS NEUROSCIENCE, 2007, 8 (01) :57-69

[7] Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J].

Bravo, Javier A. ;

Forsythe, Paul ;

Chew, Marianne V. ;

Escaravage, Emily ;

Savignac, Helene M. ;

Dinan, Timothy G. ;

Bienenstock, John ;

Cryan, John F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16050-16055

[8]

CANGIANO C, 1983, J BIOL CHEM, V258, P8949

[9]

Carabotti M, 2015, ANN GASTROENTEROL, V28, P203

[10] Is Altered BDNF Biosynthesis a General Feature in Patients with Cognitive Dysfunctions? [J].

Carlino, Davide ;

De Vanna, Maurizio ;

Tongiorgi, Enrico .

NEUROSCIENTIST, 2013, 19 (04) :345-353

← 1 2 3 4 5 6 7 8 9 10 →