The emergency management thought of the fourth generation of collective leadership of the party and state has been mature gradually through response to major public health emergencies like SARS, Sanlu milk powder event and A (H1N1). This paper takes crisis management thought of the fourth generation of central collective leadership response to major public health emergency as example.Adopting case study method. Inducing and summarizing the emergency management thought and main content that include emergency preparedness thought with the emphasis on normalized crisis preparation, emergency early warning thought with the emphasis on information transparency, emergency rescue thought with the emphasis on the people -oriented concept, and post -emergency rehabilitation thought with the emphasis on restoring social order. And then putting forward the perfecting policy suggestions for major public health emergency management, so that provide ideological reference and theoretical reference for the new generation of collective leadership responding to major public health emergencies.