Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

被引：33

作者：

Ali, Alaa M. G. ^{[1
,9
]}

Schmidt, Marjanka K. ^{[10
,11
]}

Bolla, Manjeet K. ^{[2
]}

Wang, Qin ^{[2
]}

Gago-Dominguez, M. ^{[16
]}

Esteban Castelao, J. ^{[17
]}

Carracedo, Angel ^{[16
,25
]}

Munoz Garzon, Victor ^{[18
]}

Bojesen, Stig E. ^{[26
,27
]}

Nordestgaard, Borge G. ^{[26
,27
]}

Flyger, Henrik ^{[28
]}

Chang-Claude, Jenny ^{[31
]}

Vrieling, Alina ^{[12
,31
]}

Rudolph, Anja ^{[31
]}

Seibold, Petra ^{[31
]}

Nevanlinna, Heli ^{[32
]}

Muranen, Taru A. ^{[32
]}

Aaltonen, Kirsimari ^{[32
,33
,34
]}

Blomqvist, Carl ^{[33
,34
]}

Matsuo, Keitaro ^{[36
]}

Ito, Hidemi ^{[36
]}

Iwata, Hiroji ^{[37
]}

Horio, Akiyo ^{[37
]}

John, Esther M. ^{[38
]}

Sherman, Mark ^{[40
]}

Lissowska, Jolanta ^{[42
]}

Figueroa, Jonine ^{[41
]}

Garcia-Closas, Montserrat ^{[5
,6
]}

Anton-Culver, Hoda ^{[39
]}

Shah, Mitul

Hopper, John L. ^{[43
]}

Trichopoulou, Antonia ^{[44
,45
]}

Bueno-de-Mesquita, Bas ^{[7
,13
,14
,55
]}

Krogh, Vittorio ^{[46
]}

Weiderpass, Elisabete ^{[35
,47
,48
,49
]}

Andersson, Anne ^{[50
]}

Clavel-Chapelon, Francoise ^{[52
,53
,54
]}

Dossus, Laure ^{[52
,53
,54
]}

Fagherazzi, Guy ^{[52
,53
,54
]}

Peeters, Petra H. ^{[15
]}

Olsen, Anja ^{[29
]}

Wishart, Gordon C. ^{[4
]}

Easton, Douglas F. ^{[2
]}

Borgquist, Signe ^{[51
]}

Overvad, Kim ^{[30
]}

Barricarte, Aurelio ^{[19
,20
]}

Gonzalez, Carlos A. ^{[21
]}

Sanchez, Maria-Jose ^{[22
,23
]}

Amiano, Pilar ^{[24
]}

Riboli, Elio ^{[7
]}

机构：

[1] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England

[2] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England

[3] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge CB1 8RN, England

[4] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Cambridge, England

[5] Inst Canc Res, Div Genet & Epidemiol, Sutton, Surrey, England

[6] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

[7] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England

[8] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England

[9] South Egypt Canc Inst, Dept Biostat & Canc Epidemiol, Assiut, Egypt

[10] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Psychosocial Res & Epidemiol, Amsterdam, Netherlands

[11] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands

[12] Radboud Univ Nijmegen, Med Ctr, Dept Hlth Evidence, NL-6525 ED Nijmegen, Netherlands

[13] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[14] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[15] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Dept Epidemiol, Utrecht, Netherlands

[16] Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago IDIS, Serv Galego Saude SERGAS, Genom Med Grp,Galician Fdn Genom Med, Santiago De Compostela, Spain

[17] Univ Hosp Vigo, Galicia Hlth Serv SERGAS, Oncol & Genet Unit, Vigo, Spain

[18] Univ Hosp Vigo, Dept Radiotherapy, Vigo, Spain

[19] Navarre Publ Hlth Inst, Pamplona, Spain

[20] Consortium Biomed Res Epidemiol & Publ Hlth, CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[21] Catalan Inst Oncol ICO, Chief Unit Nutr Environm & Canc, Barcelona, Spain

[22] Andalusian Sch Publ Hlth, Granada, Spain

[23] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[24] BioDonostia Res Inst, Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[25] King Abdulaziz Univ, Jeddah 21413, Saudi Arabia

[26] Copenhagen Gen Populat Study, Copenhagen, Denmark

[27] Univ Copenhagen, Copenhagen Univ Hosp, Herlev Hosp, Dept Clin Biochem, Copenhagen, Denmark

[28] Univ Copenhagen, Copenhagen Univ Hosp, Herlev Hosp, Dept Breast Surg, Copenhagen, Denmark

[29] Danish Canc Soc, Res Ctr, Copenhagen, Denmark

[30] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark

[31] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[32] Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland

[33] Univ Helsinki, Dept Oncol, Helsinki, Finland

[34] Univ Helsinki, Cent Hosp, Helsinki, Finland

[35] Samfundet Folkhalsan, Helsinki, Finland

[36] Aichi Canc Ctr, Cent Hosp, Div Epidemiol & Prevent, Nagoya, Aichi 464, Japan

[37] Aichi Canc Ctr, Cent Hosp, Dept Breast Oncol, Nagoya, Aichi 464, Japan

[38] Canc Prevent Inst Calif, Fremont, CA USA

[39] Univ Calif Irvine, Dept Epidemiol, Irvine, CA USA

[40] NCI, Div Canc Epidemiol & Genet, NIH, US Dept HHS, Bethesda, MD 20892 USA

[41] NCI, Div Canc Epidemiol & Genet, Rockville, MD USA

[42] M Sklodowska Curie Mem Canc Ctr & Inst Oncol, Warsaw, Poland

[43] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

[44] Hellen Hlth Fdn, Athens, Greece

[45] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece

[46] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[47] Univ Tromso, Artic Univ Norway, Dept Community Med, Tromso, Norway

[48] Canc Registry Norway, Dept Res, Oslo, Norway

[49] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[50] Umea Univ, Dept Radiat Sci, Umea, Sweden

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2014年 / 23卷 / 06期

基金：

芬兰科学院; 英国医学研究理事会;

关键词：

POSTMENOPAUSAL WOMEN; RECEPTOR STATUS; DIETARY FACTORS; RISK-FACTORS; RECURRENCE; MORTALITY; NUTRITION; FAT;

D O I：

10.1158/1055-9965.EPI-13-0901

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods: A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for "moderate drinkers" versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results: We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate postdiagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85-1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73-0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre-or postdiagnosis alcohol consumption is associated with breast cancer-specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer-specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion: There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer-specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer-specific mortality in ER-negative disease. Impact: Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer. (C) 2014 AACR.

引用

页码：934 / 945

页数：12

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