Recognition of H3K9me1 by maize RNA-directed DNA methylation factor SHH2∞

被引：5
|
作者：
Wang, Yuhua [1 ,2 ]
Zhou, Xuelin [1 ,2 ,3 ]
Luo, Jinyan [1 ,2 ]
Lv, Suhui [4 ]
Liu, Rui [4 ]
Du, Xuan [4 ]
Jia, Bei [1 ,2 ]
Yuan, Fengtong [1 ,2 ,3 ]
Zhang, Heng [1 ,2 ]
Du, Jiamu [4 ]
机构：
[1] Chinese Acad Sci, Ctr Excellence Mol Plant Sci, Natl Key Lab Plant Mol Genet, Shanghai 201602, Peoples R China
[2] Chinese Acad Sci, Ctr Excellence Mol Plant Sci, Shanghai Ctr Plant Stress Biol, Shanghai 201602, Peoples R China
[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[4] Southern Univ Sci & Technol, Inst Plant & Food Sci, Key Lab Mol Design Plant Cell Factory, Guangdong Higher Educ Inst,Sch Life Sci, Shenzhen 518055, Peoples R China
来源：
JOURNAL OF INTEGRATIVE PLANT BIOLOGY | 2021年 / 63卷 / 06期
基金：
中国国家自然科学基金;
关键词：
epigenetics; maize; RNA-directed DNA methylation; SAWADEE domain; SHH2; EPIGENETIC PATHWAY; POLYMERASE IV; COMPONENT; READOUT; L3MBTL1;
D O I：
10.1111/jipb.13103
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA-directed DNA methylation (RdDM) is a plant-specific de novo DNA methylation pathway, which has extensive cross-talk with histone modifications. Here, we report that the maize RdDM regulator SAWADEE HOMEODOMAIN HOMOLOG 2 (SHH2) is an H3K9me1 reader. Our structural studies reveal that H3K9me1 recognition is achieved by recognition of the methyl group via a classic aromatic cage and hydrogen-bonding and salt-bridge interactions with the free protons of the mono-methyllysine. The di- and tri-methylation states disrupt the polar interactions, decreasing the binding affinity. Our study reveals a mono-methyllysine recognition mechanism which potentially links RdDM to H3K9me1 in maize.
引用
收藏
页码：1091 / 1096
页数：6
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