Detection of DNA Hybridization Beyond the Debye Screening Length by CMOS Capacitive Sensors

被引：2

作者：

Lin, Chang-Hung ^{[1
,2
]}

Lee, Yuan-Chieh ^{[1
,2
]}

Yang, Chia-Min ^{[3
]}

Lu, Michael S-C ^{[1
,2
]}

机构：

[1] Natl Tsing Hua Univ, Dept Elect Engn, Hsinchu 300044, Taiwan

[2] Natl Tsing Hua Univ, Inst Elect Engn, Hsinchu 300044, Taiwan

[3] Natl Tsing Hua Univ, Dept Chem, Hsinchu 300044, Taiwan

来源：

IEEE ELECTRON DEVICE LETTERS | 2022年 / 43卷 / 08期

关键词：

Sensors; DNA; Electrodes; Capacitive sensors; Capacitance; Biosensors; Frequency modulation; CMOS; Debye length; interdigitated electrodes; LABEL-FREE; APTASENSOR; ARRAY;

D O I：

10.1109/LED.2022.3182784

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Capacitive sensors are very promising to provide label-free and real-time biological detection for point-of-care diagnostic applications. However, the Debye charge screening effect severely hinders the detection under high ionic strength condition, such as in human serum. Therefore, most measurements are made indirectly in diluted solutions. To solve this problem, electric field modulation between the interdigitated sensing electrodes is applied in this study to increase the Debye length. For DNA (deoxyribonucleic acid) measurements, the two designs operating around 90 and 40 MHz exhibited sensitivities of 2.6 fF/log[DNA] and 10.8 fF/log[DNA] up to 100 fM and a response time of 12 minutes.

引用

页码：1319 / 1322

页数：4

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