Glucose Transporter Expression of an Esophageal Gastrointestinal Tumor Detected by F-18 FDG PET/CT

被引：14

作者：

Kaida, Hayato ^{[1
,2
]}

Ishibashi, Masatoshi ^{[1
,2
]}

Yuzuriha, Miya ^{[1
,2
]}

Kurata, Seiji ^{[1
,2
]}

Arikawa, Syunji ^{[1
,2
]}

Kawahara, Akihiko ^{[3
]}

Uozumi, Jun ^{[1
,2
]}

Uchida, Masafumi ^{[1
,2
]}

Kobayashi, Maiko ^{[1
,2
]}

Hirose, Yasumitsu ^{[1
,2
]}

Fujita, Hiromasa ^{[4
]}

Kage, Masayoshi ^{[3
]}

Hayabuchi, Naofumi ^{[1
,2
]}

机构：

[1] Kurume Univ, Sch Med, Div Nucl Med, PET Ctr, Kurume, Fukuoka 830, Japan

[2] Kurume Univ, Sch Med, Dept Radiol, Kurume, Fukuoka 830, Japan

[3] Kurume Univ Hosp, Dept Diagnost Pathol, Kurume, Fukuoka, Japan

[4] Kurume Univ, Sch Med, Dept Surg, Kurume, Fukuoka 830, Japan

来源：

CLINICAL NUCLEAR MEDICINE | 2010年 / 35卷 / 07期

关键词：

fluorine-18 fluorodeoxyglucose positron emission; tomography/computed tomography; gastrointestinal tumor; esophagus; glucose transporter; STROMAL TUMORS; GIST; IMATINIB;

D O I：

10.1097/RLU.0b013e3181e05d79

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A 74-year-old woman had dysphagia and underwent esophago-gastroduodenoscopy. A giant submucosal tumor was seen from the middle to the lower esophagus. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-18 FDG-PET/CT) was performed and F-18 FDG was found to accumulate in the submucosal tumor. The maximum standardized uptake value of the early phase was 4.93 and that of the delayed phase was 6.48. Gastrointestinal stromal tumor (GIST) was confirmed by both fine needle aspiration under endoscopic ultrasound and postoperative histopathologic findings. We stained the postoperative histopathologic specimen to investigate glucose transporter (GLUT) expression using immunohistochemistry, which revealed that GLUT-1 had a weak expression on membranes and GLUT-4 had a strong expression on membranes or in cytoplasm. GLUT-3 had no expression on membranes or in cytoplasm. Esophageal GIST is rare and the relationship between GLUT expression and F-18 FDG accumulation in GIST is probably rare.

引用

页码：505 / 509

页数：5

共 19 条

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