A one-pot method for the efficient conversion of aryl- and acyl-substituted methyl alcohols into chlorides

被引：6
|
作者：
Lai, GF
Tan, PZ
Ghoshal, P
机构：
[1] Yale Univ, Sch Med, Dept Psychiat, West Haven, CT 06516 USA
[2] Chemo Dynam Inc, Sayreville, NY USA
来源：
SYNTHETIC COMMUNICATIONS | 2003年 / 33卷 / 10期
关键词：
D O I：
10.1081/SCC-120018934
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot and efficient conversion of aryl- and acyl-substituted methyl alcohols into the corresponding chlorides is described, which involved tosylation with tosyl chloride and triethylamine in the presence of a catalytic amount of 4-(dimethylamino)pyridine (DMAP) in CH2Cl2, followed by methanol-facilitated replacement of the tosylates with chloride. This mild method is readily amenable to large-scale synthesis.
引用
收藏
页码：1727 / 1732
页数：6
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