SWI/SNF proteins as targets in cancer therapy

被引：15

作者：

Schiaffino-Ortega, Santiago ^{[2
]}

Balinas, Carlos ^{[2
]}

Cuadros, Marta ^{[1
,2
]}

Medina, Pedro P. ^{[1
,2
]}

机构：

[1] Univ Granada, Dept Biochem & Mol Biol, E-18071 Granada, Spain

[2] Univ Granada, Pfizer, Andalusian Reg Govt, GENyO,Ctr Genom & Oncol Res, Granada, Spain

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2014年 / 7卷

关键词：

SWI/SNF complex; Cancer therapy; Epigenetic; Tumor suppressor; Synthetic lethality; Leukemia; Lung cancer; BRG1; SMARCA4; BRM; SMARCA2; MAX; MYC; CHROMATIN-REMODELING FACTOR; LEUKEMIA MAINTENANCE; SYNTHETIC LETHAL; BRG1; COMPLEXES;

D O I：

10.1186/s13045-014-0081-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.

引用

页数：3

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