Annexins family: insights into their functions and potential role in pathogenesis of sarcoidosis

被引：84

作者：

Mirsaeidi, Mehdi ^{[1
]}

Gidfar, Sanaz ^{[2
]}

Ann Vu ^{[3
]}

Schraufnagel, Dean ^{[4
]}

机构：

[1] Univ Miami, Miller Sch Med, Div Pulm Crit Care Sleep & Allergy, Dept Med, 1600 NW 10th Ave 7060A, Miami, FL 33136 USA

[2] Univ Illinois, Dept Ophthalmol, Chicago, IL 60680 USA

[3] Univ Miami, Dept Med, Miami, FL 33136 USA

[4] Univ Illinois, Div Pulm & Crit Care, Chicago, IL USA

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2016年 / 14卷

关键词：

Annexin; Sarcoidosis; Apoptosis; Calcium; ADRENAL-MEDULLARY; LUNG-CANCER; PROTEIN; ASSOCIATION; EXPRESSION; SYNEXIN; IDENTIFICATION; APOPTOSIS; MEMBRANE; ANXA11;

D O I：

10.1186/s12967-016-0843-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Annexins are Ca2+-regulated phospholipid-binding proteins that play an important role in the cell life cycle, exocytosis, and apoptosis. Annexin A11 is one of the oldest vertebrate annexins that has a crucial role in sarcoidosis pathogenesis. The mechanism of effect in sarcoidosis granuloma cells may be due to alterations in apoptosis. Immune cells with a specific mutation at protein location 230 are resistant to apoptosis and consequently have continued effects on inflammation and progression of sarcoidosis. The mechanism of action of annexin A11 may be based upon alterations in delivering calcium to two different apoptosis pathways (caspase and P53).

引用

页数：9

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