Single-Walled Carbon Nanotube-Based Chemiresistive Affinity Biosensors for Small Molecules: Ultrasensitive Glucose Detection

被引：143

作者：

Cella, Lakshmi N. ^{[1
,2
]}

Chen, Wilfred ^{[1
,2
]}

Myung, Nosang V. ^{[1
]}

Mulchandani, Ashok ^{[1
,2
]}

机构：

[1] Univ Calif Riverside, Dept Chem & Environm Engn, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Cell Mol & Dev Biol Grad Program, Riverside, CA 92521 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 14期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

FIELD-EFFECT TRANSISTORS; ELECTRICAL DETECTION; FLOW IMMUNOSENSOR; CONCANAVALIN-A; BINDING; PROTEIN; SENSOR; IMMUNOASSAY; MECHANISM; DEVICES;

D O I：

10.1021/ja100503b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report for the first time single-walled carbon nanotube (SWNT)-based chemiresistive affinity sensors for highly sensitive and selective detection of small and/or weakly charged or uncharged molecules using a displacement format. The detection of glucose, a small, weakly charged molecule, by displacement of plant lectin (concavalin A) bound to a polysaccharide (dextran) immobilized on SWNTs with picomolar sensitivity and selectivity over other sugars and human serum proteins is demonstrated as a proof of concept.

引用

页码：5024 / +

页数：5

共 38 条

[1] Concanavalin A for in vivo glucose sensing: A biotoxicity review [J].

Ballerstadt, Ralph ;

Evans, Colton ;

McNichols, Roger ;

Gowda, Ashok .

BIOSENSORS & BIOELECTRONICS, 2006, 22 (02) :275-284

[2] Reversible control of carbon nanotube aggregation for a glucose affinity sensor [J].

Barone, Paul W. ;

Strano, Michael S. .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (48) :8138-8141

[3] Nano Aptasensor for Protective Antigen Toxin of Anthrax [J].

Cella, Lakshmi N. ;

Sanchez, Pablo ;

Zhong, Wenwan ;

Myung, Nosang V. ;

Chen, Wilfred ;

Mulchandani, Ashok .

ANALYTICAL CHEMISTRY, 2010, 82 (05) :2042-2047

[4] An investigation of the mechanisms of electronic sensing of protein adsorption on carbon nanotube devices [J].

Chen, RJ ;

Choi, HC ;

Bangsaruntip, S ;

Yenilmez, E ;

Tang, XW ;

Wang, Q ;

Chang, YL ;

Dai, HJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (05) :1563-1568

[5] Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors [J].

Chen, RJ ;

Bangsaruntip, S ;

Drouvalakis, KA ;

Kam, NWS ;

Shim, M ;

Li, YM ;

Kim, W ;

Utz, PJ ;

Dai, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) :4984-4989

[6] Electrical detection of hepatitis C virus RNA on single wall carbon nanotube-field effect transistors [J].

Dastagir, Tawab ;

Forzani, Erica S. ;

Zhang, Ruth ;

Amlani, Islamshah ;

Nagahara, Larry A. ;

Tsui, Raymond ;

Tao, Nongjian .

ANALYST, 2007, 132 (08) :738-740

[7] Electrical detection of femtomolar DNA via gold-nanoparticle enhancement in carbon-nanotube-network field-effect transistors [J].

Dong, Xiaochen ;

Lau, Ching Man ;

Lohani, Anup ;

Mhaisalkar, Subodh G. ;

Kasim, Johnson ;

Shen, Zexiang ;

Ho, Xinning ;

Rogers, John A. ;

Li, Lain-Jong .

ADVANCED MATERIALS, 2008, 20 (12) :2389-+

[8] Evidence for high-cavacity bidirectional glucose transport across the endoplasmic reticulum membrane by genetically encoded fluorescence resonance energy transfer nanosensors [J].

Fehr, M ;

Takanaga, H ;

Ehrhardt, DW ;

Frommer, WB .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (24) :11102-11112

[9] Dual-labeled glucose binding protein for ratiometric measurements of glucose [J].

Ge, XD ;

Tolosa, L ;

Rao, G .

ANALYTICAL CHEMISTRY, 2004, 76 (05) :1403-1410

[10]

Gordon S.H., 1970, European Journal of Biochemistry, V16, P549

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