West Nile virus: crossing the blood-brain barrier

被引：60
作者：
Diamond, MS [1 ]
Klein, RS
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA
来源：
NATURE MEDICINE | 2004年 / 10卷 / 12期
关键词：
D O I：
10.1038/nm1204-1294
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A study in mice traces the path of West Nile virus into the brain. Viral replication in peripheral tissues triggers a Toll-like receptor inflammatory response that alters the blood-brain barrier (pages 1366–1373).
引用
收藏
页码：1294 / 1295
页数：2
相关论文
共 9 条
  • [1] The blood-brain barrier: an overview - Structure, regulation, and clinical implications
    Ballabh, P
    Braun, A
    Nedergaard, M
    [J]. NEUROBIOLOGY OF DISEASE, 2004, 16 (01) : 1 - 13
  • [2] Innate sensing of viruses by toll-like receptors
    Boehme, KW
    Compton, T
    [J]. JOURNAL OF VIROLOGY, 2004, 78 (15) : 7867 - 7873
  • [3] The influence of cytokines on the integrity of the blood-brain barrier in vitro
    deVries, HE
    BlomRoosemalen, MCM
    vanOosten, M
    deBoer, AG
    vanBerkel, TJC
    Breimer, DD
    Kuiper, J
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 1996, 64 (01) : 37 - 43
  • [4] Innate and adaptive immune responses determine protection against disseminated infection by West Nile encephalitis virus
    Diamond, MS
    Shrestha, B
    Mehlhop, E
    Sitati, E
    Engle, M
    [J]. VIRAL IMMUNOLOGY, 2003, 16 (03) : 259 - 278
  • [5] Does Toll-like receptor 3 play a biological role in virus infections?
    Edelmann, KH
    Richardson-Burns, S
    Alexopoulou, L
    Tyler, KL
    Flavell, RA
    Oldstone, MBA
    [J]. VIROLOGY, 2004, 322 (02) : 231 - 238
  • [6] TNF-alpha opens a paracellular route for HIV-1 invasion across the blood-brain barrier
    Fiala, M
    Looney, DJ
    Stins, M
    Way, DD
    Zhang, L
    Gan, XH
    Chiappelli, F
    Schweitzer, ES
    Shapshak, P
    Weinand, M
    Graves, MC
    Witte, M
    Kim, KS
    [J]. MOLECULAR MEDICINE, 1997, 3 (08) : 553 - 564
  • [7] West Nile virus: where are we now?
    Granwehr, BP
    Lillibridge, KM
    Higgs, S
    Mason, PW
    Aronson, JF
    Campbell, GA
    Barrett, ADT
    [J]. LANCET INFECTIOUS DISEASES, 2004, 4 (09) : 547 - 556
  • [8] Toll-like receptor control of the adaptive immune responses
    Iwasaki, A
    Medzhitov, R
    [J]. NATURE IMMUNOLOGY, 2004, 5 (10) : 987 - 995
  • [9] Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
    Wang, T
    Town, T
    Alexopoulou, L
    Anderson, JF
    Fikrig, E
    Flavell, RA
    [J]. NATURE MEDICINE, 2004, 10 (12) : 1366 - 1373
1