Processing and characterization of silk sericin from Bombyx mori and its application in biomaterials and biomedicines

被引:210
作者
Cao, Ting-Ting [1 ]
Zhang, Yu-Qing [1 ]
机构
[1] Soochow Univ, Sch Biol & Basic Med Sci, Silk Biotechnol Lab, RM702-2303,199 Renai Rd, Suzhou 215123, Peoples R China
来源
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2016年 / 61卷
关键词
Sericin; Non-sericin component; Biomaterials; Biomedidnes; Bioactivity; REDUCING OXIDATIVE STRESS; FREE FREEZING MEDIUM; SERUM-FREE MEDIUM; COCOON SHELL; PROTEIN SERICIN; AMINO-ACIDS; TRANSGENIC SILKWORM; L-ASPARAGINASE; ISLET CULTURE; WASTE-WATER;
D O I
10.1016/j.msec.2015.12.082
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Bombyx mod silk is composed of 60-80% fibroin, 15-35% sericin and 1-5% non-sericin component including wax, pigments, sugars and other impurities. For two decades, the protein-based silk fibroin was extensively used in the research and development of medical biomaterials and biomedicines. Sericin is frequently ignored and abandoned as a byproduct or waste in the processing of traditional silk fabrics, silk floss or modem silk biomaterials. However, similar to fibroin, sericin is not only a highly useful biological material, but also a lot of biological activity. Moreover, the non-sericin component present with sericin in the cocoon shell also has a strong biological activity. In this review, the extraction and recovery methods of sericin and the non-sericin component from the cocoon layer are reported, and their composition, properties and biological activity are described to produce a comprehensive report on biomedical materials and biological drugs. In addition, related problems or concerns present in the research and development of sericin are discussed, and a potential application of sericin in sustainable development is also presented. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:940 / 952
页数:13
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