Transcriptome-wide association study reveals two genes that influence mismatch negativity

被引：10

作者：

Bhat, Anjali ^{[1
,3
,9
,11
,12
]}

Irizar, Haritz ^{[1
]}

Thygesen, Johan Hilge ^{[1
]}

Kuchenbaecker, Karoline ^{[1
,5
]}

Pain, Oliver ^{[2
]}

Adams, Rick A. ^{[1
,4
]}

Zartaloudi, Eirini ^{[1
]}

Harju-Seppanen, Jasmine ^{[1
,14
]}

Austin-Zimmerman, Isabelle ^{[1
]}

Wang, Baihan ^{[1
]}

Muir, Rebecca ^{[1
]}

Summerfelt, Ann ^{[6
]}

Du, Xiaoming Michael ^{[6
]}

Bruce, Heather ^{[6
]}

O'Donnell, Patricio ^{[6
,7
,13
]}

Srivastava, Deepak P. ^{[9
,11
,12
]}

Friston, Karl ^{[3
]}

Hong, L. Elliot ^{[6
]}

Hall, Mei-Hua ^{[7
,8
]}

Bramon, Elvira ^{[1
,4
,9
,10
]}

机构：

[1] UCL, Div Psychiat, London, England

[2] Kings Coll London, Social Genet & Dev Psychiat Ctr, Inst Psychiat Psychol & Neurosci, London, England

[3] UCL, Wellcome Ctr Human Neuroimaging, London, England

[4] UCL, Inst Cognit Neurosci, London, England

[5] UCL, UCL Genet Inst, London, England

[6] Univ Maryland, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD USA

[7] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA

[8] McLean Hosp, Psychosis Neurobiol Lab, 115 Mill St, Belmont, MA 02178 USA

[9] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England

[10] Camden & Islington NHS Fdn Trust, London, England

[11] Kings Coll London, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London, England

[12] Kings Coll London, MRC, Ctr Neurodev Disorders, London, England

[13] Takeda Pharmaceuticals, Cambridge, MA USA

[14] UCL, Dept Clin Educ & Hlth Psychol, London, England

来源：

CELL REPORTS | 2021年 / 34卷 / 11期

基金：

英国惠康基金; 美国国家卫生研究院; 欧盟地平线“2020”; 英国医学研究理事会;

关键词：

SCHIZOPHRENIA; ENDOPHENOTYPE; HERITABILITY; BRAIN; LOCI; METAANALYSIS; INVOLVEMENT; PSYCHOSIS; CHANNELS; RISK;

D O I：

10.1016/j.celrep.2021.108868

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mismatch negativity (MMN) is a differential electrophysiological response measuring cortical adaptability to unpredictable stimuli. MMN is consistently attenuated in patients with psychosis. However, the genetics of MMN are uncharted, limiting the validation of MMN as a psychosis endophenotype. Here, we perform a transcriptome-wide association study of 728 individuals, which reveals 2 genes (FAM89A and ENGASE) whose expression in cortical tissues is associated with MMN. Enrichment analyses of neurodevelopmental expression signatures show that genes associated with MMN tend to be overexpressed in the frontal cortex during prenatal development but are significantly downregulated in adulthood. Endophenotype ranking value calculations comparing MMN and three other candidate psychosis endophenotypes (lateral ventricular volume and two auditory-verbal learning measures) find MMN to be considerably superior. These results yield promising insights into sensory processing in the cortex and endorse the notion of MMN as a psychosis endophenotype.

引用

页数：13

共 84 条

[1] Adams Rick A, 2013, Front Psychiatry, V4, P47, DOI 10.3389/fpsyt.2013.00047
[2] IL-13-induced airway mucus production is attenuated by MAPK13 inhibition
Alevy, Yael G.
Patel, Anand C.
Romero, Arthur G.
Patel, Dhara A.
Tucker, Jennifer
Roswit, William T.
Miller, Chantel A.
Heier, Richard F.
Byers, Derek E.
Brett, Tom J.
Holtzman, Michael J.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (12) : 4555 - 4568
[3] [Anonymous], 2013, DIAGNOSTIC STAT MANU
[4] Analysis of shared heritability in common disorders of the brain
Anttila, Verneri
Bulik-Sullivan, Brendan
Finucane, Hilary K.
Walters, Raymond K.
Bras, Jose
Duncan, Laramie
Escott-Price, Valentina
Falcone, Guido J.
Gormley, Padhraig
Malik, Rainer
Patsopoulos, Nikolaos A.
Ripke, Stephan
Wei, Zhi
Yu, Dongmei
Lee, Phil H.
Turley, Patrick
Grenier-Boley, Benjamin
Chouraki, Vincent
Kamatani, Yoichiro
Berr, Claudine
Letenneur, Luc
Hannequin, Didier
Amouyel, Philippe
Boland, Anne
Deleuze, Jean-Francois
Duron, Emmanuelle
Vardarajan, Badri N.
Reitz, Christiane
Goate, Alison M.
Huentelman, Matthew J.
Kamboh, M. Ilyas
Larson, Eric B.
Rogaeva, Ekaterina
St George-Hyslop, Peter
Hakonarson, Hakon
Kukull, Walter A.
Farrer, Lindsay A.
Barnes, Lisa L.
Beach, Thomas G.
Demirci, F. Yesim
Head, Elizabeth
Hulette, Christine M.
Jicha, Gregory A.
Kauwe, John S. K.
Kaye, Jeffrey A.
Leverenz, James B.
Levey, Allan I.
Lieberman, Andrew P.
Pankratz, Vernon S.
Poon, Wayne W.
[J]. SCIENCE, 2018, 360 (6395) : 1313 - +
[5] Mismatch negativity indexes illness-specific impairments of cortical plasticity in schizophrenia: A comparison with bipolar disorder and Alzheimer's disease
Baldeweg, Torsten
Hirsch, Steven R.
[J]. INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2015, 95 (02) : 145 - 155
[6] Hallucinations both in and out of context: An active inference account
Benrimoh, David
Parr, Thomas
Adams, Rick A.
Friston, Karl
[J]. PLOS ONE, 2019, 14 (08):
[7] Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, Amy R.
Sung, Yun J.
Brown, Michael R.
Winkler, Thomas W.
Kraja, Aldi T.
Ntalla, Ioanna
Schwander, Karen
Chasman, Daniel, I
Lim, Elise
Deng, Xuan
Guo, Xiuqing
Liu, Jingmin
Lu, Yingchang
Cheng, Ching-Yu
Sim, Xueling
Vojinovic, Dina
Huffman, Jennifer E.
Musani, Solomon K.
Li, Changwei
Feitosa, Mary F.
Richard, Melissa A.
Noordam, Raymond
Baker, Jenna
Chen, Guanjie
Aschard, Hugues
Bartz, Traci M.
Ding, Jingzhong
Dorajoo, Rajkumar
Manning, Alisa K.
Rankinen, Tuomo
Smith, Albert, V
Tajuddin, Salman M.
Zhao, Wei
Graff, Mariaelisa
Alver, Maris
Boissel, Mathilde
Chai, Jin Fang
Chen, Xu
Divers, Jasmin
Evangelou, Evangelos
Gao, Chuan
Goel, Anuj
Hagemeijer, Yanick
Harris, Sarah E.
Hartwig, Fernando P.
He, Meian
Horimoto, Andrea R. V. R.
Hsu, Fang-Chi
Hung, Yi-Jen
Jackson, Anne U.
[J]. NATURE GENETICS, 2019, 51 (04) : 636 - +
[8] Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder
Bergen, S. E.
O'Dushlaine, C. T.
Ripke, S.
Lee, P. H.
Ruderfer, D. M.
Akterin, S.
Moran, J. L.
Chambert, K. D.
Handsaker, R. E.
Backlund, L.
Osby, U.
McCarroll, S.
Landen, M.
Scolnick, E. M.
Magnusson, P. K. E.
Lichtenstein, P.
Hultman, C. M.
Purcell, S. M.
Sklar, P.
Sullivan, P. F.
[J]. MOLECULAR PSYCHIATRY, 2012, 17 (09) : 880 - 886
[9] The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse
Blake, Judith A.
Bult, Carol J.
Eppig, Janan T.
Kadin, James A.
Richardson, Joel E.
[J]. NUCLEIC ACIDS RESEARCH, 2014, 42 (D1) : D810 - D817
[10] Prediction of Psychosis by Mismatch Negativity
Bodatsch, Mitja
Ruhrmann, Stephan
Wagner, Michael
Mueller, Ralf
Schultze-Lutter, Frauke
Frommann, Ingo
Brinkmeyer, Juergen
Gaebel, Wolfgang
Maier, Wolfgang
Klosterkoetter, Joachim
Brockhaus-Dumke, Anke
[J]. BIOLOGICAL PSYCHIATRY, 2011, 69 (10) : 959 - 966

← 1 2 3 4 5 6 7 8 9 →