Resveratrol attenuates myocardial injury in septic rats via inhibition of the JAK2/STAT3 signaling pathway

被引：0

作者：

Ji, Zhiyong ^{[1
]}

Li, Yubo ^{[2
]}

Sun, Guoqiang ^{[1
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Cardiol, 3302 Jilin Rd, Changchun 130031, Peoples R China

[2] Changchun Med Coll, Changchun 130031, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 02期

关键词：

Resveratrol; sepsis; myocardial injury; JAK2/STAT signaling; INDUCED CARDIAC DYSFUNCTION; LUNG INFLAMMATION; SEPSIS; SHOCK; ACTIVATION; MECHANISMS; MICE; APOPTOSIS; HEART; SIRT1;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Resveratrol (Res) is reported to exert anti-inflammatory and anti-oxidative properties. Sepsis-induced myocardial injury is tightly associated with inflammation. However, the mechanisms underlying the protective effect of Res remain unclear. The present study investigated the protective effect of Res on myocardial injury in septic rats and the role of the Janus Kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway. Res treatment was found to significantly inhibit the activation of JAK2 and STAT3 in myocardial tissue. It also attenuated the level of pro-inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-1 beta in the serum and myocardial tissue. In addition, Res alleviated myocardial apoptosis. In conclusion, the results indicate that Res exhibits substantial therapeutic potential for the treatment of sepsis-induced myocardial injury via JAK2/STAT3 signaling inhibition.

引用

页码：1724 / 1731

页数：8

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