On the Road to a HIV Cure Moving Beyond Berlin and London

被引：15

作者：

Jilg, Nikolaus ^{[1
,2
]}

Li, Jonathan Z. ^{[2
,3
]}

机构：

[1] Massachusetts Gen Hosp, 55 Fruit St, Boston, MA 02114 USA

[2] Harvard Med Sch, 25 Shattuck St, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2019年 / 33卷 / 03期

基金：

美国国家卫生研究院;

关键词：

HIV; HIV persistence; HIV cure; HIV vaccine; Broadly neutralizing antibodies (bNAbs); Long-term remission; Posttreatment controllers; PTC; CD4(+) T-CELLS; BROADLY NEUTRALIZING ANTIBODIES; RALTEGRAVIR INTENSIFICATION; ANTIRETROVIRAL THERAPY; STEM; CCR5; REPLICATION; INFECTION; RESERVOIR; BLOOD;

D O I：

10.1016/j.idc.2019.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Berlin patient, a famous example for human immunodeficiency virus (HIV) cure, had received a bone marrow transplantation with an HIV resistance mutation. The authors describe his case and others that had shown HIV control, like the Mississippi baby who was started on antiretroviral therapy very early after birth, and posttreatment controllers, like the VISCONTI cohort. Moreover, the authors outline various strategies, oftentimes informed by these individuals, that have been tried in vitro, in animal models, or in human trials, to deplete the latent reservoir, which is considered the basis of HIV persistence and the obstacle to cure.

引用

页码：857 / +

页数：13

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