Cyclodextrin-based Polymeric Nanoparticles as Efficient Carriers for Anticancer Drugs

被引：29
作者：
Duchene, Dominique [1 ]
Cavalli, Roberta [2 ]
Gref, Ruxandra [3 ]
机构：
[1] Univ Paris South, Fac Pharm, UMR CNRS 8612, Galien Inst, 5 Rue Jean Baptiste Clement, F-92290 Chatenay Malabry, France
[2] Univ Turin, Dept Drug Sci & Technol, I-10124 Turin, Italy
[3] Univ Paris South, UMR CNRS 8214, Inst Mol Sci, F-92290 Chatenay Malabry, France
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2016年 / 17卷 / 03期
关键词：
Cancer; cyclodextrins; nanoparticles; polymers; solubility; stability; cytotoxicity; PH-RESPONSIVE NANOPARTICLES; CHITOSAN/CYCLODEXTRIN NANOPARTICLES; IMMUNOADJUVANT PROPERTIES; BIOADHESIVE CAPACITY; DELIVERY; CANCER; NANOSPONGES; MICELLES; DOXORUBICIN; PACLITAXEL;
D O I：
10.2174/1389201017666151030104944
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Among the difficulties encountered in the treatment of cancer are the physico-chemical properties of the chemotherapeutic agents; in particular low water solubility and low stability, resulting in poor efficacy. Due to their capability to form molecular inclusions with apolar molecules (or part of them) cyclodextrins constitute a powerful tool to prepare more efficient chemotherapeutic delivery systems such as nanoparticles. This review focuses on polymeric nanoparticles for cancer therapy prepared from either cyclodextrin molecules, or polymer and cyclodextrins.
引用
收藏
页码：248 / 255
页数：8
相关论文
共 73 条
[71]   CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes [J].
Yong, Dawei ;
Luo, Yu ;
Du, Fang ;
Huang, Jin ;
Lu, Wei ;
Dai, Zhaoyun ;
Yu, Jiahui ;
Liu, Shiyuan .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 105 :31-36
[72]   Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: Permeability and pharmacokinetic study [J].
Zabaleta, Virginia ;
Ponchel, Gilles ;
Salman, Hesham ;
Agueeros, Maite ;
Vauthier, Christine ;
Irache, Juan M. .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2012, 81 (03) :514-523
[73]   Facile Engineering of Biocompatible Materials with pH-Modulated Degradability [J].
Zhang, Jianxiang ;
Jia, Yi ;
Li, Xiaodong ;
Hu, Yingqian ;
Li, Xiaohui .
ADVANCED MATERIALS, 2011, 23 (27) :3035-+
12345678