Cyclodextrin-based Polymeric Nanoparticles as Efficient Carriers for Anticancer Drugs

被引：29
作者：
Duchene, Dominique [1 ]
Cavalli, Roberta [2 ]
Gref, Ruxandra [3 ]
机构：
[1] Univ Paris South, Fac Pharm, UMR CNRS 8612, Galien Inst, 5 Rue Jean Baptiste Clement, F-92290 Chatenay Malabry, France
[2] Univ Turin, Dept Drug Sci & Technol, I-10124 Turin, Italy
[3] Univ Paris South, UMR CNRS 8214, Inst Mol Sci, F-92290 Chatenay Malabry, France
来源：
CURRENT PHARMACEUTICAL BIOTECHNOLOGY | 2016年 / 17卷 / 03期
关键词：
Cancer; cyclodextrins; nanoparticles; polymers; solubility; stability; cytotoxicity; PH-RESPONSIVE NANOPARTICLES; CHITOSAN/CYCLODEXTRIN NANOPARTICLES; IMMUNOADJUVANT PROPERTIES; BIOADHESIVE CAPACITY; DELIVERY; CANCER; NANOSPONGES; MICELLES; DOXORUBICIN; PACLITAXEL;
D O I：
10.2174/1389201017666151030104944
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Among the difficulties encountered in the treatment of cancer are the physico-chemical properties of the chemotherapeutic agents; in particular low water solubility and low stability, resulting in poor efficacy. Due to their capability to form molecular inclusions with apolar molecules (or part of them) cyclodextrins constitute a powerful tool to prepare more efficient chemotherapeutic delivery systems such as nanoparticles. This review focuses on polymeric nanoparticles for cancer therapy prepared from either cyclodextrin molecules, or polymer and cyclodextrins.
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页码：248 / 255
页数：8
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