Localization of G-protein-coupled receptors in health and disease

被引：66

作者：

Edwards, SW ^{[1
]}

Tan, CM ^{[1
]}

Limbird, LE ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2000年 / 21卷 / 08期

关键词：

D O I：

10.1016/S0165-6147(00)01513-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

G-protein-coupled receptors (GPCRs) represent a superfamily of proteins, characterized by seven transmembrane alpha-helices, that signal through interactions with a family of heterotrimeric GTP-binding proteins, referred to as G proteins. The broad range of physiological functions associated with GPCRs indicates that a better understanding of these receptors and their regulation can provide a solid foundation for novel pharmacological interventions in a variety of disease states.

引用

页码：304 / 308

页数：5

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