Swine Granulosa Cells Show Typical Endothelial Cell Characteristics

被引：17
作者：
Basini, Giuseppina [1 ]
Falasconi, Irene [1 ]
Bussolati, Simona [1 ]
Grolli, Stefano [1 ]
Di Lecce, Rosanna [1 ]
Grasselli, Francesca [1 ]
机构：
[1] Univ Parma, Dipartimento Sci Med Vet, Via Taglio 10, I-43126 Parma, Italy
来源：
REPRODUCTIVE SCIENCES | 2016年 / 23卷 / 05期
关键词：
ovary; granulosa cell; angiogenesis; PROGENITOR CELLS; NITRIC-OXIDE; ANGIOGENIC ACTIVITY; EXPRESSION; MODULATOR; FOLLICLE; ENDOGLIN; PECAM-1; VEGF;
D O I：
10.1177/1933719115612130
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Granulosa cells, which belong to the somatic compartment of the ovarian follicle, are actively involved as endocrine cells in follicle growth. Recently, it has been proposed that these cells are not terminally differentiated and possess multipotency. Therefore, we cultured swine granulosa cells in specific endothelial cell culture medium (EBM-2), and phenotypic and functional characteristics of endothelial cells were assessed. The collected data suggest that these endocrine cells can also behave as endothelial cells, therefore potentially contributing to follicular angiogenesis, a crucial process in follicle growth and selection.
引用
收藏
页码：630 / 637
页数：8
相关论文
共 32 条
[11]   Antiangiogenesis in swine ovarian follicle: A potential role for 2-methoxyestradiol [J].
Basini, Giuseppina ;
Bussolati, Simona ;
Santini, Sujen Eleonora ;
Bianchi, Federica ;
Careri, Maria ;
Mangia, Alessandro ;
Musci, Marilena ;
Grasselli, Francesca .
STEROIDS, 2007, 72 (08) :660-665
[12]   Nitric oxide in follicle development and oocyte competence [J].
Basini, Giuseppina ;
Grasselli, Francesca .
REPRODUCTION, 2015, 150 (01) :R1-R9
[13]   Angiogenic activity of swine granulosa cells: effects of hypoxia and vascular endothelial growth factor Trap R1R2, a VEGF blocker [J].
Bianco, F ;
Basini, G ;
Grasselli, F .
DOMESTIC ANIMAL ENDOCRINOLOGY, 2005, 28 (03) :308-319
[14]  
Boonyaprakob U, 2005, CAN J VET RES, V69, P215
[15]   Role of PECAM-1 in Arteriogenesis and Specification of Preexisting Collaterals [J].
Chen, Zhongming ;
Rubin, Janet ;
Tzima, Ellie .
CIRCULATION RESEARCH, 2010, 107 (11) :1355-1363
[16]   Endoglin (CD105): A marker of tumor vasculature and potential target for therapy [J].
Dallas, Nikolaos A. ;
Samuel, Shaija ;
Xia, Ling ;
Fan, Fan ;
Gray, Michael J. ;
Lim, Sherry J. ;
Ellis, Lee M. .
CLINICAL CANCER RESEARCH, 2008, 14 (07) :1931-1937
[17]   Expression of Mesenchymal Stem Cells-Related Genes and Plasticity of Aspirated Follicular Cells Obtained from Infertile Women [J].
Dzafic, Edo ;
Stimpfel, Martin ;
Novakovic, Srdjan ;
Cerkovnik, Petra ;
Virant-Klun, Irma .
BIOMED RESEARCH INTERNATIONAL, 2014, 2014
[18]   Plasticity of granulosa cells: on the crossroad of stemness and transdifferentiation potential [J].
Dzafic, Edo ;
Stimpfel, Martin ;
Virant-Klun, Irma .
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2013, 30 (10) :1255-1261
[19]   Outgrowth endothelial cells isolated and expanded from human peripheral blood progenitor cells cells for endothelialization as a potential source of autologous of silk fibroin biomaterials [J].
Fuchs, Sabine ;
Motta, Antonella ;
Migliaresi, Claudio ;
Kirkpatrick, Charles James .
BIOMATERIALS, 2006, 27 (31) :5399-5408
[20]  
Grasselli F, 2003, J PHYSIOL PHARMACOL, V54, P361
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