Swine Granulosa Cells Show Typical Endothelial Cell Characteristics

被引：17
作者：
Basini, Giuseppina [1 ]
Falasconi, Irene [1 ]
Bussolati, Simona [1 ]
Grolli, Stefano [1 ]
Di Lecce, Rosanna [1 ]
Grasselli, Francesca [1 ]
机构：
[1] Univ Parma, Dipartimento Sci Med Vet, Via Taglio 10, I-43126 Parma, Italy
来源：
REPRODUCTIVE SCIENCES | 2016年 / 23卷 / 05期
关键词：
ovary; granulosa cell; angiogenesis; PROGENITOR CELLS; NITRIC-OXIDE; ANGIOGENIC ACTIVITY; EXPRESSION; MODULATOR; FOLLICLE; ENDOGLIN; PECAM-1; VEGF;
D O I：
10.1177/1933719115612130
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Granulosa cells, which belong to the somatic compartment of the ovarian follicle, are actively involved as endocrine cells in follicle growth. Recently, it has been proposed that these cells are not terminally differentiated and possess multipotency. Therefore, we cultured swine granulosa cells in specific endothelial cell culture medium (EBM-2), and phenotypic and functional characteristics of endothelial cells were assessed. The collected data suggest that these endocrine cells can also behave as endothelial cells, therefore potentially contributing to follicular angiogenesis, a crucial process in follicle growth and selection.
引用
收藏
页码：630 / 637
页数：8
相关论文
共 32 条
[1]   The vascular character of ovarian follicular granulosa cells: phenotypic and functional evidence for endothelial-like cell population [J].
Antczak, M ;
Van Blerkom, J .
HUMAN REPRODUCTION, 2000, 15 (11) :2306-2318
[2]  
Antczak M, 2001, Reprod Biomed Online, V2, P188
[3]   Vascular endothelial growth factor production in growing pig antral follicles [J].
Barboni, B ;
Turriani, M ;
Galeati, G ;
Spinaci, M ;
Bacci, ML ;
Forni, M ;
Mattioli, M .
BIOLOGY OF REPRODUCTION, 2000, 63 (03) :858-864
[4]   Is nitric oxide an autocrine modulator of bovine granulosa cell function? [J].
Basini, G ;
Baratta, M ;
Ponderato, N ;
Bussolati, S ;
Tamanini, C .
REPRODUCTION FERTILITY AND DEVELOPMENT, 1998, 10 (06) :471-478
[5]   Hydroxyestrogens inhibit angiogenesis in swine ovarian follicles [J].
Basini, G. ;
Bussolati, S. ;
Santini, S. E. ;
Bianchi, F. ;
Careri, M. ;
Mangia, A. ;
Musci, M. ;
Grasselli, F. .
JOURNAL OF ENDOCRINOLOGY, 2008, 199 (01) :127-135
[6]   The effects of reduced oxygen tension on swine granulosa cell [J].
Basini, G ;
Bianco, F ;
Grasselli, F ;
Tirelli, M ;
Bussolati, S ;
Tamanini, C .
REGULATORY PEPTIDES, 2004, 120 (1-3) :69-75
[7]   Isolation of endothelial cells and pericytes from swine corpus luteum [J].
Basini, G. ;
Falasconi, I. ;
Bussolati, S. ;
Grolli, S. ;
Ramoni, R. ;
Grasselli, F. .
DOMESTIC ANIMAL ENDOCRINOLOGY, 2014, 48 :100-109
[8]   The axonal guidance factor netrin-1 as a potential modulator of swine follicular function [J].
Basini, G. ;
Cortimiglia, C. ;
Baioni, L. ;
Bussolati, S. ;
Grolli, S. ;
Ramoni, R. ;
Grasselli, F. .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2011, 331 (01) :41-48
[9]   Selenium stimulates estradiol production in bovine granulosa cells: possible involvement of nitric oxide [J].
Basini, G ;
Tamanini, C .
DOMESTIC ANIMAL ENDOCRINOLOGY, 2000, 18 (01) :1-17
[10]   Reactive oxygen species and anti-oxidant defences in swine follicular fluids [J].
Basini, Giuseppina ;
Simona, Bussolati ;
Santini, Sujen Eleonora ;
Grasselli, Francesca .
REPRODUCTION FERTILITY AND DEVELOPMENT, 2008, 20 (02) :269-274
1234